Changes in Immunological Status in Children with Broncho-Obstructive Syndrome and Bronchial Asthma

Abstract

It has long been known that the immune system is a component of the homeostatic triangle, which also includes the nervous and endocrine systems. The modern concept of the heterogeneity of the immune response in relation to its cellular and humoral forms, indicating the absence of a single pattern of protection for a particular infection, makes it possible to distinguish among children suffering from a viral or bacterial infection a different dominant mechanism of immune defense - cellular Th1-like, or humoral , Th2-like In most infections, resolution of the pathological process is realized with a mixed type of immune response, including both cellular and humoral forms. protection in the acute phase of the disease. The modern concept of the pathogenesis of bronchial asthma is based on the recognition of the leading role of immune mechanisms in its development. Changes in the immune response found in this disease are considered as a consequence of sensitization of the body and a significant influence on the functioning of genetic and environmental factors. IgE- mediated allergic reactions are leading in the development of bronchial asthma in children.