Study and Diagnosis of Some Physiological Parameters and Hormones in Female White Rats with Induced Abortion by B. Abortus

Abstract

This research set out to examine the effects of Brucella abortus infection on pregnant and nonpregnant female rats, along with a few other physiological characteristics. Infected female rats (n = 15), infected pregnant female rats (n = 15), and a control group. The rats came from the animal facility at Al-Qadisiyah University's College of Veterinary Medicine. The findings of this investigation demonstrated Within 24 hours of infection with B. abortus biotype 1, all of the rats exhibited symptoms of lethargy, loss of appetite, and fever. Within the span of 7 days of monitoring, the greatest rectal temperature was 38.5 degrees Celsius at hour 72. Throughout the study, no clinical abnormalities were noted in the control rats. Compared to the control group, the levels of LH and FSH were significantly lower in the brucellosis-infected and nonpregnant participants as well as the brucellosis-infected and pregnant participants (P0.05; Fig. 1 and 2). In comparison to the first group and the placebo group, the second group had the most improvement. The current study's findings are depicted in Fig. 3 at the (P0.05) level of significance. The levels of the IgG were a substantial rising in the group that was infected with brucellosis and was not pregnant, as well as in the group that was infected with brucellosis and was pregnant compared to the control group. In comparison to the first group and the placebo group, the second group had the most improvement. The current study's findings are depicted in Fig. 4 at the (P0.05) level of significance. When compared to the control group, the MDA levels were significantly higher in both the brucellosis-infected and -pregnant and -infected and pregnant groups. In comparison to the first group and the placebo group, the second group had the most improvement. In contrast, as depicted in Fig. 5 at (P0.05), GSH levels were significantly lower in the brucellosis-infected and non-pregnant group and the brucellosis-infected and pregnant group when compared to the control group. In comparison to the first group and the placebo group, the second group had the most improvement.