Congenital Heart Disease in Infants of Diabetic Mothers
Keywords:
Congenital Heart Disease, Infant, Diabetic MothersAbstract
Women with diabetes in pregnancy (type 1, type 2, and gestational) are at increased risk of adverse pregnancy outcomes with higher fetal and neonatal mortality rate. The risk of congenital anomalies increased in infants of diabetic mothers with over -presentation of congenital heart defects. The aim of our study is to detect congenital heart disease in infants of diabetic mothers. A cross sectional study was carried out among sample of infants of diabetic mothers in Al- Zahraa teaching hospital at period from first of February to first of November, 2023. Information was gathered according to data collection sheet that included: name, age (gestational and postnatal), sex, mode of delivery, type of diabetes mellitus (type 1, 2, and gestational), maternal compliance to treatment, and other symptoms like macrosomia (body weight more than 4 kg), hypoglycemia, and hypocalcemia. Data have been obtained by standard laboratory procedures including random blood sugar, serum calcium, and echo study. A total of 80 infants were enrolled in this study between 1 to 40 days of age with mean age of 6.7 days, 43 were males and 37 were females. The percentage of congenital heart disease was 27.5% with a percentage of 27.9%, 27.09 in males and females respectively. The statistically significant difference in this study was between (macrosomia, advanced maternal age, low mean random blood sugar, low mean serum calcium) and abnormal echocardiographic.
References
Suda-Całus, M., Dąbrowska, K., & Gulczyńska, E. Infant of a diabetic mother: clinical presentation, diagnosis and treatment. Pediatric Endocrinology Diabetes and Metabolism. 2024; 30(1), 36-41.
Shamoon, M., Ahsan, M., Maqbool, T., Aslam, R., & Yaseen, A. Congenital heart defects in neonates born to diabetic mother (IDM): A single center experience. The Professional Medical Journal. 2020; 27(05), 950-956.
Radwan, M. A., El Mansori, N. A., Elfergani, M. A., Halies, F. R., & Lawgali, M. A. Neonatal morbidity pattern among infants born to diabetic mothers at Jamhouria hospital, Benghazi-Libya.
Samanth, J., Padmakumar, R., Vasudeva, A., Lewis, L., Nayak, K., & Nayak, V. Persistent subclinical myocardial dysfunction among infants of diabetic mothers. Journal of Diabetes and its Complications. 2022; 36(1), 108079.
Nakano, H., Fajardo, V. M., & Nakano, A. The role of glucose in physiological and pathological heart formation. Developmental biology. 2021; 475, 222-233.
Foteva, V., Fisher, J. J., Qiao, Y., & Smith, R. Does the micronutrient molybdenum have a role in gestational complications and placental health?. Nutrients. 2023;15(15), 3348.
Zhang, D., Wang, X., Qu, J., Li, Y., Shi, T., & Zhang, W. Hypertensive Diseases in Female and Pregnancy. Secondary Hypertension: Screening, Diagnosis and Treatment. 2020; 569-638.
Mishra, V., Lui, K., Schelonka, R. L., Maheshwari, A., & Jain, R. (2024). Infants of Diabetic Mothers. Principles of Neonatology, 200-206.
Calvo, C. D. P., Capellini-Suárez, A., & Hernandez, A. P. M. Diabetic Fetopathy. Med Clin Res Open Access, 21(2), 4.
Redko, O. K., Petrashenko, V. O., & Loboda, A. M. Neonatology. (2021).
Yuan, S. M. Infantile Hypertrophic Cardiomyopathies: Starting from the Pathogenesis. medp cardiol vasc med. 2021; 1 (1): mpcvm-202110001. MedPress Cardiology and Vascular Medicine Shi-Min Yuan, Department of Cardiothoracic Surgery, Fujian Medical University, Putian, 351100.
Frier BM, Fisher M, Diabetes Mellitus. In: Nicholus AB, Nicki RC, Brain RW (eds) Davidson’s Principles and Practice of Medicine, 21st edition. Churchil Livingstone. Edinburg. 2010; p 798-806.
Mansi, H. Types of Congenital Anomalies among Children at Bint Al-Huda Teaching Hospital in Al-Nasiriyah City, South of Iraq. Bahrain Medical Bulletin. 2022; 44(1).
Abu- Sulaiman RM, Subaih B. congenital heart disease in infants of diabetic mothers: echocardiographic study. pediatrCardiol. 2004; 25(2): 137-40.
Roodpeyma S, Rafieyian S, Khosravi N, Hashemi A. Cardiovascular complications in infants of diabetic mothers: An observational study in a pediatric cardiology clinic in Tehran. J Compr Ped. 2013; 3(3): 119-23.
