Abstract
The analysis of the associative relationship of the gene polymorphism in the IL-4 promoter region in positions (C589T) with the risk of developing RB in 119 children with recurrent bronchitis aged 2 to 7 years and in 110 apparently healthy children of the same age in the Uzbek population.
The results of the study showed statistically significant differences in the frequency distribution of alleles and genotypes of the C589T C>T polymorphic locus of the IL-4 gene in patients with RB. The frequency of the unfavorable allele of the T and T / T genotype was significantly more often determined in patients with RB against the background of lymphotic-hypoplastic diathesis, which indicates a predisposing role of the rs2243250 polymorphism of the IL-4 gene to the development of recurrent bronchitis in LGD children in the Uzbek population. Was carried out.
References
Akparova A.Yu. et al. The role of genes of cytokines IL-4 and TNF-α in the development of predisposition to bronchial asthma and chronic obstructive pulmonary disease // Molecular genetic research methods in medicine and biology. KarSMU. 2012.S. 15-22.
Bobomurotov T.A., Sharipova O.A., Yusupova U.U., Bakhronov Sh.S., Abdurakhmanov Zh.N. The influence of ecological environment on the homeostatic system and the level of interleukins at acute bronchitis in early age children // Central Asian Journal of Medicine. V0l. 2020; №1. pp.84-91.
Cho M.H., McDonald M.L., Zhou X. [et al.] Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and metaanalysis / //Lancet Resp. Med. – 2014. – Vol. 2, N 3. – Р. 214–225 doi: http://dx.doi.org/10.1016/S2213-2600(14)70002-5.
Fishwick D., Sen D., Barber C. et al. Occupational chronic obstructive pulmonary disease: a standard of care. Occup. Med. (Lond). 2015; 65 (4): 270-282. DOI: 10.1093/occmed / kqv019.
Firdavs Oripov, Sophia Blinova, Tashpulat Dekhkanov, Salim Davlatov. (2021). Development of immune structures of the leaning intestine of rabbits in early postnatal ontogenesis//international Journal of Pharmaceutical Research, 13, -P299-301. DOI: https: //doi.org /10.31838 /ijpr/ 2021. 13.01.042
Henao M.I., Montes C., Paris S.C., Garcia L.F. Cytokine gene polymorphisms in Colombian patients with different clinical presentations of tuberculosis. Tuberculosis, 2006, vol. 86, pp. 11-19.
Nesterenko Z.V. Recurrent bronchitis as a phenotypic variant of acute bronchitis in children. Ukrainskij medichnij visnik 2012; 15: 6: P.121-123.
Oliya Sharipova, Sherzod Bakhronov, Turdikul Bobomuratov, Dilshoda Akramova. The Role of Polymorphism Of Cytokin Genes Against Inflammation And Anti-Inflammation In Patients With Bronchus-Lung Diseases // Annals of the Romanian Society for Cell Biology, ISSN:1583-6258, Vol. 25, Issue 6, 2021, P. 2330-2346
Polyakov V.V., Senatorova A.S. The clinical significance of endothelial dysfunction in children with recurrent obstructive bronchitis and bronchial asthma. Mezdunarodnij meditsinskij zhurnal 2012; 2:32-36. (Ukr).
Priola A.M., Priola S.M. Imaging of thymus in myasthenia gravis:from thymic hyperplasia to thymic tumor. Clin. Radiol. 2014; 69(5): p.230—245.
Raisky D.V., Dzhumagaziev A.A. Bezrukova D.A. Recurrent bronchitis in children: the state of the problem // Astrakhan medical journal. 2014 T. 9, No. 1 p. 2937
Ribeiro R.M., Perelson A.S. Determining thymic output quantitatively: using models to interpret experimental T-cell receptor excision circle (TREC) data. Immunol. Rev. 2007; 216: 21—34.
Rosenwasser, L.J. Promoter polymorphisms predisposing to the development of asthma and atopy / L.J. Rosenwasser, L. Borish // Clin.Exp. Allergy -1998. Vol. 5№13. P.26-28.
Sharipova O.A., Bobomuratov T. A., Bahranov Sh. S. Features of physical development and bone mineral density in children with chronic bronchitis. European science review. - Austria, Vienna. 2016. -№11-12, -P.96-100.
Statistical materials on the activities of healthcare institutions of the Republic of Uzbekistan in 2015. Tashkent 2016
Sh.S. Bakhronov, O.A. Sharipova, T.A. Bobomuratov, M.A. Melieva, Zh.N. Abdurahmanov Clinical significance of T-31C polymorphism of IL-1β gene in recurrent bronchitis in children. Annals of the Romanian Society for Cell Biology ISSN: 1583-6258, Vol. 25, Issue 3, 2021, P. 4742-4748