Genetic Disposition Markers of Development of Recurrent Bronchitis in Children with Lymphatic-Hypoplastic Diathesis

The analysis of the associative relationship of the gene polymorphism in the IL-4 promoter region in positions (C589T) with the risk of developing RB in 119 children with recurrent bronchitis aged 2 to 7 years and in 110 apparently healthy children of the same age in the Uzbek population.

The results of the study showed statistically significant differences in the frequency distribution of alleles and genotypes of the C589T C>T polymorphic locus of the IL-4 gene in patients with RB. The frequency of the unfavorable allele of the T and T / T genotype was significantly more often determined in patients with RB against the background of lymphotic-hypoplastic diathesis, which indicates a predisposing role of the rs2243250 polymorphism of the IL-4 gene to the development of recurrent bronchitis in LGD children in the Uzbek population. Was carried out.