Down-Regulation of Shank3 Gene in Patients with Autism Spectrum Disorders and its Reflects in Ability to Speech, Education and Social Communication

Mahdi Saber Al-Deresawi; Aseel Razak Al-Rekaabi

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Mahdi Saber Al-Deresawi College of Science / University of Wasit
Aseel Razak Al-Rekaabi College of Science / University of Wasit

Vol. 3 No. 7 (2025): International Journal of Pediatrics and Genetics

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July 28, 2025

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The objective of this study was to detect the effect of Shank3 gene expression levels and their related to speech ability, education and social communication in children with Autism Spectrum Disorders. Forty ASD patients who were admitted to the (Rahman Specialist Centre for the care and service autistic children/ Baghdad/Iraq) and ten children apparently healthy group. Patients and healthy control group aged from (3-10) years. According the sex the results showed a significant increase in male (77.5%) compare to female (22.5%). Patients with ASD recorded a weak ability to speech in high significance increase (72.5%) compared to another group. While the ability to education and ability to social communication were moderate in high significant increase (65.5%) in patient with ASD. The quantitative Real-Time PCR Results showed a significant decreased (0.374 ±0.18) in ASD patients when compared to the healthy control group (1.00 ±0.00). The down-regulation of Shank3 appear a positive correlation to Ability to Speech, Ability to Education and Ability to social communication.

Al-Deresawi, M. S., & Al-Rekaabi, A. R. (2025). Down-Regulation of Shank3 Gene in Patients with Autism Spectrum Disorders and its Reflects in Ability to Speech, Education and Social Communication. International Journal of Pediatrics and Genetics , 3(7), 32–40. Retrieved from https://medicaljournals.eu/index.php/IJPG/article/view/2012

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Journal title	International Journal of Pediatrics and Genetics
Initials	Int.Jour.Ped.Gen
Frequency	12 issues per year
Prefix DOI	10.xxxxx
Online ISSN	XXXX-XXXX
Editor In Chief	Mehwish Alam []
Publisher	Medical Journals Press

International Journal of Pediatrics and Genetics

Down-Regulation of Shank3 Gene in Patients with Autism Spectrum Disorders and its Reflects in Ability to Speech, Education and Social Communication

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