Endometriosis and its Impact on the Urinary System: a Uro Gynecological Review
Downloads
Endometriosis is marked by the establishment of endometrial-like tissue outside the uterine cavity and is, therefore, an area of serious morbidity where this review aims to interrogate the effects of endometriosis on the urinary system with a view towards discussing its incidence, diagnostic difficulty, and treatment furthermore for this review, a thorough literature search was carried out on papers published between 1996 and 2024 colloquially for the urinary endometriosis (UTE) and its significance on patient care. Our study suggests that UTE could be found in 1-6% of females with endometriosis and that the bladder is almost always the affected organ also the literature highlights the need for rapid diagnosis and immediate multidisciplinary treatment including surgical and medical options and despite technical innovations in laparoscopic treatment techniques and hormonal therapies, a large proportion of patients still suffer from delays in diagnosis and residual symptoms finally we conclude that a multidisciplinary approach is desirable for better outcomes in patients with endometriosis involving the urinary system and that further research is needed to increase knowledge.
1. Berveiller P., Ropert S., Mir O., Becker C.M., Missmer S.A., Zondervan K.T. Endometriosis. N. Engl. J. Med. 2020;383:193–194. doi: 10.1056/nejmc2013221. [DOI] [PubMed] [Google Scholar]
2. Johnson N.P., Hummelshoj L., Abrao M.S., Adamson G.D., Allaire C., Amelung V., Andersson E., Becker C., Ardal K.B.B., Bush D., et al. Consensus on current management of endometriosis. Hum. Reprod. 2013;28:1552–1568. doi: 10.1093/humrep/det050. [DOI] [PubMed] [Google Scholar]
3. Leonardi M., Lam A., Abrão M.S., Johnson N.P., Condous G. Ignored Because It Is Benign—It Is Time to Treat Endometriosis as if It Were Cancer. J. Obstet. Gynaecol. Can. 2020;42:507–509. doi: 10.1016/j.jogc.2019.12.014. [DOI] [PubMed] [Google Scholar]
4. Johnson N.P., Hummelshoj L., Adamson G.D., Keckstein J., Taylor H.S., Abrao M.S., Bush D., Kiesel L., Tamimi R., Sharpe-Timms K.L., et al. World Endometriosis Society consensus on the classification of endometriosis. Hum. Reprod. 2016;32:315–324. doi: 10.1093/humrep/dew293. [DOI] [PubMed] [Google Scholar]
5. Berlanda N., Vercellini P., Carmignani L., Aimi G., Amicarelli F., Fedele L. Ureteral and Vesical Endometriosis. Obstet. Gynecol. Surv. 2009;64:830–842. doi: 10.1097/OGX.0b013e3181c4bc3a. [DOI] [PubMed] [Google Scholar]
6. Seracchioli R., Mabrouk M., Montanari G., Manuzzi L., Concetti S., Venturoli S. Conservative laparoscopic management of urinary tract endometriosis (UTE): Surgical outcome and long-term follow-up. Fertil. Steril. 2010;94:856–861. doi: 10.1016/j.fertnstert.2009.04.019. [DOI] [PubMed] [Google Scholar]
7. Prystowsky J. B., Stryker S. J., Ujiki G. T., et al. Gastrointestinal endometriosis. Incidence and indications for resection. Archives of Surgery. 1988;123 (7):855–858. doi: 10.1001/archsurg 1988.01400310069011. [DOI] [PubMed] [Google Scholar]
8. Rana R., Sharma S., Narula H., et al. A case of recto-sigmoid endometriosis mimicking carcinoma. Springer Plus. 2016;5:p. 643. doi: 10.1186/s40064-016-2221-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
9. Petros J. G., Spirito N., Gosshein R. Endometriosis causing colon obstruction in two postmenopausal women. Mount Sinai Journal of Medicine. 1992;59 (4):362–365. [PubMed] [Google Scholar]
10. Bergqvist A. Extragenital endometriosis: a review. European Journal of Surgery. 1992;158 (1):7–12. [PubMed] [Google Scholar]
11. Rossini L., Ribeiro P., Rodrigues F., et al. Transrectal ultrasound—techniques and outcomes in the management of intestinal endometriosis. Endoscopic Ultrasound. 2012;1 (1):23–35. doi: 10.7178/eus.01.005. [DOI] [PMC free article] [PubMed] [Google Scholar]
12. Coronado C., Franklin R. R., Lotze E. C., Bailey R., Valdés C. T. Surgical treatment of symptomatic colorectal endometriosis. Fertility and Sterility. 1990;53 (3):411–416. doi: 10.1016/s0015-0282 (16)53332-9. [DOI] [PubMed] [Google Scholar]
13. Lambert S, Santulli P, Chouzenoux S, et al. Endometriosis: Increasing concentrations of serum interleukin-1β b and interleukin-1sRII is associated with the deep form of this pathology. J Gynecol Obstet Biol Reprod (Paris) 2014;43:735–43. doi: 10.1016/j.jgyn.2014.06.014. [DOI] [PubMed] [Google Scholar]
14. Santulli P, Borghese B, Noël JC, Fayt I, Anaf V, de Ziegler D, et al. Hormonal therapy deregulates prostaglandin-endoperoxidase synthase 2 (PTGS2) expression in endometriotic tissues. J Clin Endocrinol Metab. 2014;99:881–90. doi: 10.1210/jc 2013-2950. [DOI] [PubMed] [Google Scholar]
15. Bukulmez O, Hardy DB, Carr BR, Word RA, Mendelson CR. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Endocrinology. 2008;149:1190–204. doi: 10.1210/en.2007-0665. [DOI] [PMC free article] [PubMed] [Google Scholar]
16. Banu SK, Lee J, Speights VO, Jr, Starzinski-Powitz A, Arosh JA. Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms. Mol Endocrinol. 2009;23:1291–305. doi: 10.1210/me 2009-0017. [DOI] [PMC free article] [PubMed] [Google Scholar]
17. De Ziegler D, Gayet V, Aubriot FX, Fauque P, Streuli I, Wolf JP, et al. Use of oral contraceptives in women with endometriosis before assisted reproduction treatment improves outcomes. Fertil Steril. 2010;94:2796–9. doi: 10.1016/j.fertnstert.2010.05.056. [DOI] [PubMed] [Google Scholar]
18. Abrao MS, Dias JA, Jr, Bellelis P, Podgaec S, Bautzer CR, Gromatsky C, et al. Endometriosis of the ureter and bladder are not associated diseases. Fertil Steril. 2009;91:1662–7. doi: 10.1016/j.fertnstert.2008.02.143. [DOI] [PubMed] [Google Scholar]
19. Seracchioli R, Mabrouk M, Montanari G, Manuzzi L, Concetti S, Venturoli S, et al. Conservative laparoscopic management of urinary tract endometriosis (UTE): Surgical outcome and long-term follow-up. Fertil Steril. 2010;94:856–61. doi: 10.1016/j.fertnstert.2009.04.019. [DOI] [PubMed] [Google Scholar]
20. Comiter CV. Endometriosis of the urinary tract. Urol Clin North Am. 2002;29:625–35. doi: 10.1016/s0094-0143 (02)00065-4. [DOI] [PubMed] [Google Scholar]


