DIAGNOSTICS OF THE ORIGIN OF DUCHENNE MYOPATHY AND MODERN CLINICAL DIAGNOSTIC METHODS

Abstract

Duchenne muscular dystrophy and Becker muscular dystrophy are X-linked recessive diseases characterized by proximal muscle weakness resulting from degeneration of muscle fibers. Becker dystrophy has a later onset and causes milder symptoms. Diagnosis is clinically suggestive and confirmed by genetic testing or analysis of the protein product of the mutant gene (dystrophin). Treatment is aimed at maintaining function with physiotherapy, orthotic braces, and orthotics. Patients with Duchenne dystrophy should be offered prednisone or deflazacort, and sometimes gene therapy.