A CROSS-SECTIONAL STUDY TO DETERMINE THE OUTCOMES OF FAMILIAL AMYLOID POLYNEUROPATHY AND PSYCHOLOGICAL FACTORS

Familial amyloid polyneuropathy Psychological factor Quality of life Symptoms Mortality and morbidity

Authors

  • Dr. Muhsin Mohammed Al Najim M.B.Ch.B., F.I.B.M.S. \ (Neurology), Ministry of Higher Education and Scientific Research, Jabir Ibn Hayyan University for Medical and Pharmaceutical Sciences, Faculty of Medicine, Al-Najaf, Iraq
  • Dr. Mustafa Fadil Abbas Lecturer, M.B.Ch.B., F.I.B.M.S. \ (Neurology) Ministry of Higher Education and Scientific Research, College of Medicine, University of Warith Alanbiyaa, Karbala, Iraq
July 20, 2024

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Background: Familial amyloid neuropathy (FAP) is a rare neurological disease that can be fatal and often leads to increased disability. Objective: The aim of this study was to assess and determine the clinical outcomes of patients with familial amyloid polyneuropathy in relation to psychological factors and quality of life. Patients and method: 72 patients with familial amyloid polyneuropathy who were between 20 and 50 years of age and had registered in the familial amyloid polyneuropathy survey were included in the study. This study used EQ-5D-3L scale assessments to evaluate psychological status as well as health-related quality of life. Results: Our study's outcomes shown that females had 43 cases that more than males with 29 cases of morbidity of familial amyloid polyneuropathy (FAP), where the most symptoms prevalent were tingling and numbness in the extremities included 22 cases, muscle weakness included 15 cases, and pain included 20 cases, Serum albumin level was 4.3 ± 0.38 g/dL, postural systolic blood pressure changes mean (SD), mm Hg was - 12.5 ± 17.6, which Disease stage based on polyneuropathy disability (PND) classified into I had 32 cases, II had 21 cases, IIIA had 11 cases, IIIB had 5 cases, and IV had 3 cases. Conclusion: The quality of life related to health in patients having familial amyloid neuropathy disorder is largely influenced by these signs and associated losses in capacities.

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