Main Article Content
Abstract
Aplastic anemia is a hematopoietic stem cell disorder characterized by loss of hematopoietic progenitors, bone marrow hypoplasia or aplasia, and cytopenias of 2 or more cell lineages (erythrocytes, leukocytes, and/or platelets). Symptoms result from the development of anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infection). Diagnosis is based on the detection of pancytopenia and bone marrow hypocellularity in the peripheral blood during bone marrow biopsy. Treatment usually includes immunosuppression with equine antithymocyte globulin and cyclosporine or bone marrow transplantation.
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References
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- Rotanov A. et al. Elderly epilepsy: neurophysiological aspects of non-psychotic mental disorders //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 192-197.
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References
Peffault de Latour R, Kulasekararaj A, Iacobelli S, et al. Eltrombopag added to immunosuppression in severe aplastic anemia. N Engl J Med 2022;386(1):11-23. doi:10.1056/NEJMoa2109965
DeZern A, Zahurak ML, Symons HJ, et al. Alternative donor BMT with posttransplant cyclophosphamide as initial therapy for acquired severe aplastic anemia [published online ahead of print, April 21, 2023]. Blood 2023; blood.2023020435. doi: 10.1182/blood.2023020435
Winkler T, Fan X, Cooper J, et al.: Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag. Blood 133(24):2575–2585, 2019. doi: 10.1182/blood.2019000478
Andryev S. et al. Experience with the use of memantine in the treatment of cognitive disorders //Science and innovation. – 2023. – Т. 2. – №. D11. – С. 282-288.
Antsiborov S. et al. Association of dopaminergic receptors of peripheral blood lymphocytes with a risk of developing antipsychotic extrapyramidal diseases //Science and innovation. – 2023. – Т. 2. – №. D11. – С. 29-35.
Asanova R. et al. Features of the treatment of patients with mental disorders and cardiovascular pathology //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 545-550.
Begbudiyev M. et al. Integration of psychiatric care into primary care //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 551-557.
Bo’Riyev B. et al. Features of clinical and psychopathological examination of young children //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 558-563.
Borisova Y. et al. Concomitant mental disorders and social functioning of adults with high-functioning autism/asperger syndrome //Science and innovation. – 2023. – Т. 2. – №. D11. – С. 36-41.
Ivanovich U. A. et al. Efficacy and tolerance of pharmacotherapy with antidepressants in non-psychotic depressions in combination with chronic brain ischemia //Science and Innovation. – 2023. – Т. 2. – №. 12. – С. 409-414.
Nikolaevich R. A. et al. Comparative effectiveness of treatment of somatoform diseases in psychotherapeutic practice //Science and Innovation. – 2023. – Т. 2. – №. 12. – С. 898-903.
Novikov A. et al. Alcohol dependence and manifestation of autoagressive behavior in patients of different types //Science and innovation. – 2023. – Т. 2. – №. D11. – С. 413-419.
Pachulia Y. et al. Assessment of the effect of psychopathic disorders on the dynamics of withdrawal syndrome in synthetic cannabinoid addiction //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 240-244.
Pachulia Y. et al. Neurobiological indicators of clinical status and prognosis of therapeutic response in patients with paroxysmal schizophrenia //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 385-391.
Pogosov A. et al. Multidisciplinary approach to the rehabilitation of patients with somatized personality development //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 245-251.
Pogosov A. et al. Rational choice of pharmacotherapy for senile dementia //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 230-235.
Pogosov S. et al. Gnostic disorders and their compensation in neuropsychological syndrome of vascular cognitive disorders in old age //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 258-264.
Pogosov S. et al. Prevention of adolescent drug abuse and prevention of yatrogenia during prophylaxis //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 392-397.
Pogosov S. et al. Psychogenetic properties of drug patients as risk factors for the formation of addiction //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 186-191.
Prostyakova N. et al. Changes in the postpsychotic period after acute polymorphic disorder //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 356-360.
Zuhridinovna, J. D., & Farrukh, S. (2024). Modern Imaging Techniques for Early Detection of Retinal Degeneration. American Journal of Bioscience and Clinical Integrity, 1(11), 22–34.
Prostyakova N. et al. Issues of professional ethics in the treatment and management of patients with late dementia //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 158-165.
Prostyakova N. et al. Sadness and loss reactions as a risk of forming a relationship together //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 252-257.
Prostyakova N. et al. Strategy for early diagnosis with cardiovascular diseaseisomatized mental disorders //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 166-172.
Rotanov A. et al. Comparative effectiveness of treatment of somatoform diseases in psychotherapeutic practice //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 267-272.
Rotanov A. et al. Diagnosis of depressive and suicidal spectrum disorders in students of a secondary special education institution //Science and innovation. – 2023. – Т. 2. – №. D11. – С. 309-315.
Rotanov A. et al. Elderly epilepsy: neurophysiological aspects of non-psychotic mental disorders //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 192-197.
Rotanov A. et al. Social, socio-cultural and behavioral risk factors for the spread of hiv infection //Science and innovation. – 2023. – Т. 2. – №. D11. – С. 49-55.
Rotanov A. et al. Suicide and epidemiology and risk factors in oncological diseases //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 398-403.
Sedenkov V. et al. Clinical and socio-demographic characteristics of elderly patients with suicide attempts //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 273-277.
Sedenkov V. et al. Modern methods of diagnosing depressive disorders in neurotic and affective disorders //Science and innovation. – 2023. – Т. 2. – №. D12. – С. 361-366.