Main Article Content
Abstract
Benign salivary gland tumors represent a heterogeneous group of neoplasms that differ in morphological characteristics, cellular composition, and clinical behavior. This review article discusses current concepts regarding the morphological subtypes of benign salivary gland tumors, including pleomorphic adenoma, monomorphic adenomas, Warthin’s tumor, and oncocytoma. Special attention is given to histological features, immunohistochemical markers, and differential diagnosis, which play a crucial role in verifying the diagnosis and determining treatment strategies. Modern morphological diagnostic methods, including histological analysis, immunohistochemistry, and molecular genetic studies, are reviewed as essential tools for accurately distinguishing between benign and malignant processes.
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References
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- Zhukovskaya E. V., Obukhov Yu. A., Karelin A. F. Swollen orofacial zone in children and adolescents (obzor literatury) //Stomatology of childhood and prevention. - 2020. - T. 20. – no. 3. - S. 244-250.
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- Rybakova M. G. i dr. Clinical and morphological parallels in the surgical treatment of patients with pleomorphic adenomyosis of the salivary glands – 2021
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- Patel EJ, Oliver JR, Liu C, Tam M, Givi B. Outcomes of carcinoma ex pleomorphic adenoma compared to de novo adenocarcinoma of major salivary glands. J Surg Oncol. 2021 Feb;123(2):446-455. doi: 10.1002/jso.26289. Epub 2020 Nov 4. PMID: 33145786.
- Russo G. et al. Expression of cell cycle–regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implications //Clinical cancer research. - 2005. - T. 11. – no. 9. - S. 3265-3273
- Salem A, Wu Y, Albarracin CT, Middleton LP, Kalhor N, Peng Y, Huang X, Aung PP, Chen H, Sahin AA, Ding Q. A Comparative Evaluation of TRPS1 and GATA3 in adenoid cystic, secretory, and acinic cell carcinomas of the breast and salivary gland. Hum Pathol. 2024 Mar; 145:42-47. doi: 10.1016/j.humpath.2024.01.004. Epub 2024 Jan 21. PMID: 38262580
- Schildt EB, Nylander K, Eriksson M, Hardell L, Magnusson A, Roos G. Expression of p53, PCNA, Ki-67 and bcl-2 in relation to risk factors in oral cancer - a molecular epidemiological study. Int J Oncol. 2003 Apr;22(4):861-8. doi: 10.3892/ijo.22.4.861. PMID: 12632080. The article was submitted 00.01.2025; approved after reviewing 00.00.2025; accepted for publication 00.00.2025.
References
Bychkov D.V., Batoroev Yu.K., Alyoshkin I.G., Kislitsina L.Yu., Kazimirsky V.A., Raevskaya L.Yu., Nemchinova S.V., Filchenkova E.V. The proliferative activity of the cell is indicated by the swelling of the slyunnyx. Bulletin VSNTs SO RAMN 2016. Volume 1., No. 5, 111, str.68-70
Vyrupaev S. V. Surgical treatment of pleomorphic adenoma of the surrounding salivary glands // Author. diss. sugar Med. Nauk., Ufa. - 2004. - S. 14.
Dregalkina A. A., Kokovina T. A. Analiz prichin retsidivov dobrokachestvennyx opukholey slyunnyx zhelet // Problemy stomatologii. 2014. No. 3. URL: https://cyberleninka.ru/article/n/analiz-prichin-retsidivov-dobrokachestvennyh-opuholey-slyunnyh-zhelez (data obrashcheniya: 20.01.2025
Engibaryan M. A., Kostoev I. S., Maksimov A. Yu., Prokhodnaya V. A., Kononenko V. I., Maksyukov S. Yu. Genetic factors influencing the survival of patients with oculo-salivary carcinoma // URMJ. 2021. #3. URL: https://cyberleninka.ru/article/n/geneticheskie-faktory-vliyaniya-na-vyzhivaemost-olnyh-rakom-okoloushnoy-slyunnoy-zhelezy (data obrashcheniya: 20.01.2025).
Zheludkova O. G. i dr. Klinicheskie manifestation of oncological diseases and detey. - 2017.
Zhukovskaya E. V., Obukhov Yu. A., Karelin A. F. Swollen orofacial zone in children and adolescents (obzor literatury) //Stomatology of childhood and prevention. - 2020. - T. 20. – no. 3. - S. 244-250.
Koblikov V. V., Sapojkova L. P., Kondrashin S. A. Complex sonography and computer tomography and diagnosis of malignant tumors indicate large saliva // Russian electronic journal radiodiagnostics. - 2015. - T. 5. – no. 2. - S. 42-46.
Malanchuk, V.A., Brodetsky I.S., Krotevich M.S. Etiological and diagnostic immunohistochemical indicators of pleomorphic adenoma slyumnyx. Vestnik KGMA im. I.K. Akhunbaeva #2-2020. Street 94-102.
Narmaksmatov B., Kurbonov R. Unikalnye osobennosti pozdnix protsessov v oblasti ofisa/13 polosti //Stomatologiya. - 2017. - T. 1. – no. 4 (69). - S. 68-72.
Nerobeev A. I., Libin P. V. Total removal of peripheral salivary glands in the case of superficial swelling of the glottis with preservation of the branch of the facial nerve //Stomatology. - 2014. - T. 93. – no. 6. - S. 47-48.
Nurov R. R., Mamatova M. Sh., Kurbankulov U. M. Epidemiology of opukholey slyunnyx (review) //European research. – 2017. – no. 8 (31). - S. 58-60.
Nurov R. R., Mamatova M. Sh.Epidemiologiya opukholey slyunnyx zhelet (obzor) //European research. - 2019. - No. 9 (31). - S. 97-104.
Patches A.I. Slyunnyx with swelling / A.I. Paches, T.D. Tabolinovskaya. - Moscow: Prakticheskaya meditsina, 2009. - 470 p.
Rybakova M. G. i dr. Clinical and morphological parallels in the surgical treatment of patients with pleomorphic adenomyosis of the salivary glands – 2021
Satorov Sh., Khodzhibekova Yu., Akramova N. Ob'emnye obrazovaniya slyunnyx zhelet: taktika luchevogo obsledovaniya //Stomatologiya. - 2020. - T. 1. – no. 2 (79). - S. 103-105.
Arrojo ML, Oliveira KK, Bettim BB, Kowalski LP, Carraro DM, Meira ITJE, Torrezan GT, Lourenço SV, Coutinho-Camillo CM. Tight junction gene expression in salivary gland tumors. Pathol Res Pract. 2022 Oct; 238:154113. doi: 10.1016/j.prp.2022.154113. Epub 2022 Sep 6. PMID: 36099718
Brar G, Smith S, Block A, Borrowdale R, Marzo SJ, Thorpe E, Leonetti JP. An institutional review of recurrent pleomorphic adenoma of the parotid gland. Ear Nose Throat J. 2024 Dec;103(12):773-778. doi: 10.1177/01455613211068574. Epub 2022 Mar 4. PMID: 35081805
Cavalcante IL, Silva Barros CCD, Colares DF, Cruz VMS, de Andrade BAB, Nonaka CFW, Rabenhorst SHB, Cavalcante RB. BubR1 and cyclin B1 immunoexpression in pleomorphic adenoma and polymorphous adenocarcinoma of minor salivary glands. Pathol Res Pract. 2024 Jan; 253:154961. doi: 10.1016/j.prp.2023.154961. Epub 2023 Nov 19. PMID: 38043194
Jauhiainen MK, Markkanen A, Atula T, Aro K, Haglund C, Söderlund-Venermo M, Mäkitie AA, Sinkkonen ST, Hagström J. Expression of toll-like receptors in recurrent pleomorphic adenoma and carcinoma ex pleomorphic adenoma. APMIS. 2025 Jan;133(1). doi: 10.1111/apm.13505. PMID: 39676674
Patel EJ, Oliver JR, Liu C, Tam M, Givi B. Outcomes of carcinoma ex pleomorphic adenoma compared to de novo adenocarcinoma of major salivary glands. J Surg Oncol. 2021 Feb;123(2):446-455. doi: 10.1002/jso.26289. Epub 2020 Nov 4. PMID: 33145786.
Russo G. et al. Expression of cell cycle–regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implications //Clinical cancer research. - 2005. - T. 11. – no. 9. - S. 3265-3273
Salem A, Wu Y, Albarracin CT, Middleton LP, Kalhor N, Peng Y, Huang X, Aung PP, Chen H, Sahin AA, Ding Q. A Comparative Evaluation of TRPS1 and GATA3 in adenoid cystic, secretory, and acinic cell carcinomas of the breast and salivary gland. Hum Pathol. 2024 Mar; 145:42-47. doi: 10.1016/j.humpath.2024.01.004. Epub 2024 Jan 21. PMID: 38262580
Schildt EB, Nylander K, Eriksson M, Hardell L, Magnusson A, Roos G. Expression of p53, PCNA, Ki-67 and bcl-2 in relation to risk factors in oral cancer - a molecular epidemiological study. Int J Oncol. 2003 Apr;22(4):861-8. doi: 10.3892/ijo.22.4.861. PMID: 12632080. The article was submitted 00.01.2025; approved after reviewing 00.00.2025; accepted for publication 00.00.2025.