CLINICAL MANIFESTATIONS OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY AND MODERN ANALYSIS OF RISK FACTORS IN PEDIATRIC PRACTICE
Keywords:
progressive multifocal leukoencephalopathy, children, JC virusAbstract
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by JC virus (JCV), mainly observed in immunodeficient conditions. This neuroinfection is considered a severe pathology with a high probability of leading to death.
References
1. Åström, K. E. Progressive multifocal leukoencephalopathy: a hitherto unrecognized complication of chronic lymphatic leukaemia and Hodgkin's disease / K. E. Åström, E. L. Mancall, E. P. Richardson // Brain. – 1958. – Vol. 81, № 1. – P. 93–111.
2. Richardson, K. Progressive multifocal leukoencephalopathy in children: clinical and radiological features / K. Richardson, S. M. Peters // Pediatric Neurology. – 1995. – Vol. 12, № 3. – P. 207–212.
3. Berger, J. R. Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease / J. R. Berger, L. Houff // Nature Reviews Neurology. – 2019. – Vol. 15, № 6. – P. 313–327.
4. Cortese, I. Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related neurological disease / I. Cortese, D. S. Reich // Nature Reviews Neurology. – 2021. – Vol. 17, № 1. – P. 37–51.
5. Gheuens, S. Progressive multifocal leukoencephalopathy in individuals with minimal or occult immunosuppression / S. Gheuens, G. Pierone, P. Peeters // Journal of Neurovirology. – 2020. – Vol. 26, № 1. – P. 1–18.
6. Williamson, E. M. JC virus infection in the setting of prophylactic treatment of multiple sclerosis / E. M. Williamson, J. R. Berger // Multiple Sclerosis Journal. – 2018. – Vol. 24, № 6. – P. 737–744.
7. Brew, B. J. Progressive multifocal leukoencephalopathy after natalizumab therapy: clinical and MRI course / B. J. Brew, S. J. Davies, P. Cinque // Annals of Neurology. – 2020. – Vol. 87, № 5. – P. 671–685.
8. Miskin, D. P. Diagnosis of Progressive Multifocal Leukoencephalopathy: comparative analysis of cerebrospinal fluid and plasma JC virus PCR assays / D. P. Miskin, R. Koralnik // Journal of Infectious Diseases. – 2019. – Vol. 219, № 7. – P. 1057–1067.
9. Monaco, M. C. JC virus infection of meningeal and choroidal epithelial cells in patients with progressive multifocal leukoencephalopathy / M. C. Monaco, B. E. Sabath, L. M. Durham // Journal of Virology. – 2018. – Vol. 92, № 17. – P. e00275-18.
10. Pavlovic, D. Progressive multifocal leukoencephalopathy: current treatment options and future perspectives / D. Pavlovic, D. C. Patera, F. Nyberg // Therapeutic Advances in Neurological Disorders. – 2021. – Vol. 14. – P. 1756286421998899.
11. Schwab, N. PML risk stratification using anti-JCV antibody index and L-selectin / N. Schwab, C. Schneider-Hohendorf, H. Wiendl // Multiple Sclerosis Journal. – 2020. – Vol. 26, № 14. – P. 1848–1858.
12. European Federation of Neurological Societies. EFNS guidelines on diagnosis and management of progressive multifocal leukoencephalopathy / EFNS Scientific Panel on Infectious Diseases // European Journal of Neurology. – 2019. – Vol. 26, № 6. – P. 854–865.
