The Role of Il-17 In Pathogenesis and Progression of Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory disease of the joints. It especially affects the sacroiliac joints and spine, as well as peripheral joints and visceral organs. AS progressively leads to inflammatory lesions and grows syndesmophytes, which cause disability and decrease quality of life. Besides, in advanced stages of disease may be accompanied with comorbidities, various disorders of heart conduction system and osteoporosis, malignancies and different complications as fracture of syndesmophytes, vision loss due to acute uveitis, aortic valve regurgitation. Early diagnosis and treatment may prevent or decrease functional disability of patients. For this need understand deeply the pathogenesis of disease. Below is given the role of IL-17 under pathways of AS.