The Role of Inactive Pituitary Adenoma in the Development of Hypogonadotropic Hypogonadism

This article explores the impact of inactive pituitary adenoma on the development of hypogonadotropic hypogonadism in women. A clinical study was conducted on 76 female patients aged 18 to 47 years to assess hormonal changes and clinical manifestations. The study found that hypogonadotropic hypogonadism is the most frequent clinical indication of pituitary insufficiency (67%) in tumors of the chiasmatic-sellar region. Key symptoms include menstrual irregularities, infertility, neurovegetative and urogenital disorders, and underdevelopment of the uterus and ovaries. The symptoms of hypogonadism typically emerge in the early stages of the disease, preceding the onset of visual and neurological impairments. The diagnosis is confirmed by reduced levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol.