Comparison of Insulin Resistance Markers in Three Groups of Iraqi Females with PCOS Taking Metformin, Spironolactone, or a Combination of Both

Huda Ali Mohammed; Asma Abdul Jaleel Swadi; Sinaa Abdul Amir Kadhim

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Dr. Huda Ali Mohammed Department of pharmacology and therapeutics/college of medicine/university of AL-Qadisiyah/Iraq
Dr. Asma Abdul Jaleel Swadi Department of pharmacology and therapeutics/college of medicine/university of AL-Qadisiyah/Iraq
Sinaa Abdul Amir Kadhim Department of pharmacology and therapeutics/college of medicine/university of AL-Qadisiyah/Iraq

Vol. 3 No. 6 (2025): International Journal of Integrative and Modern Medicine

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July 2, 2025

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Background: Polycystic ovarian syndrome (PCOS) is an endocrine disrupting syndrome that affects numerous women of childbearing age. While part of the mechanism of causation in PCOS has been identified, the exact etiology and pathophysiology are not fully understood. PCOS has been related with hormonal and metabolic changes and may predispose people to a number of other conditions such as obesity, metabolic syndrome, hypertension, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).

Aim of the study: to compaire between the consequence of metformin alone versus metformin plus spironolactone combination regarding insuline resistance(insulin resistance test) in pcos Iraqi women

Patients and methods: The existing interventional prospective training included 150 patients between the ages of 18 and 40. Based on Rotterdam principles (Rotterdam, 2004), two obstetrics and gynecology specialists diagnosed those patients with polycystic ovarian syndrome (PCOS). In Iraq's Adiwaniyah Province, the Maternity and Pediatrics Teaching Hospital served as the source of the patients. The training is scheduled for September 1st, 2024, and is extended until March 1st, 2025.

Result; all three modalities of treatment, metformin, spironolactone and combination were able to reduce mean BMI, mean HOMA-IR, mean TyG, mean and TyG-BMI, mean TG/HDL significantly (p <0.001). The amount of changes in variable initiated via combination was the best.

Conclusion; The combination of spironolactone and metformin is more operative improving insulin sensitivity in women with PCOS as evident from TyG index, TyG-BMI index and HOMA-IR and (TG/HDL) index than.

Mohammed, H. A., Swadi, A. A. J., & Kadhim, S. A. A. (2025). Comparison of Insulin Resistance Markers in Three Groups of Iraqi Females with PCOS Taking Metformin, Spironolactone, or a Combination of Both. International Journal of Integrative and Modern Medicine, 3(6), 215–221. Retrieved from https://medicaljournals.eu/index.php/IJIMM/article/view/1963

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International Journal of Integrative and Modern Medicine

Comparison of Insulin Resistance Markers in Three Groups of Iraqi Females with PCOS Taking Metformin, Spironolactone, or a Combination of Both

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