Antibiotic-Associated Intestinal Dysbiosis: Modern Strategies for Microbiota Correction
DOI:
https://doi.org/10.31149/ijimm.v4i4.2826Keywords:
Intestinal Microbiota, Antibiotics, Dysbiosis, Probiotics, Prebiotics, Synbiotics, Postbiotics, Fecal Microbiota Transplantation, MicrobiomeAbstract
Antibiotics remain one of the most widely used therapeutic agents in modern medicine for the treatment of bacterial infections. However, their use is often accompanied by disturbances in the composition of the intestinal microbiota, leading to the development of antibiotic-associated dysbiosis. This condition is characterized by a decrease in the diversity of intestinal microbial communities, a reduction in beneficial bacteria, and an increase in opportunistic microorganisms. Antibiotic-associated dysbiosis may result in diarrhea, inflammatory bowel diseases, metabolic disorders, and decreased immune defense. In recent years, modern methods for microbiota correction have been actively studied, including the use of probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation. The aim of this article is to analyze current scientific data on the mechanisms of development of antibiotic-associated intestinal dysbiosis and the effectiveness of various strategies for restoring intestinal microbiota. An analysis of recent publications on this issue has been conducted.
References
[1] P. J. Turnbaugh, R. E. Ley, M. Hamady, C. M. Fraser-Liggett, R. Knight, and J. I. Gordon, “The human microbiome project,” Nature, vol. 449, no. 7164, pp. 804–810, 2007.
[2] F. Sommer and F. Bäckhed, “The gut microbiota—masters of host development and physiology,” Nature Reviews Microbiology, vol. 11, no. 4, pp. 227–238, 2013.
[3] L. Dethlefsen and D. A. Relman, “Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation,” PNAS, vol. 108, suppl. 1, pp. 4554–4561, 2011.
[4] J. G. Bartlett, “Antibiotic-associated diarrhea,” New England Journal of Medicine, vol. 346, no. 5, pp. 334–339, 2002.
[5] Z. Kho and S. Lal, “The human gut microbiome,” Clinical Medicine, pp. 83–88, 2018.
[6] C. Jernberg, S. Löfmark, C. Edlund, and J. K. Jansson, “Long-term ecological impacts of antibiotic administration,” The ISME Journal, vol. 1, no. 1, pp. 56–66, 2007.
[7] A. Palleja et al., “Recovery of gut microbiota following antibiotic exposure,” Nature Microbiology, vol. 3, no. 11, pp. 1255–1265, 2018.
[8] L. McFarland, “Epidemiology of antibiotic-associated diarrhea,” American Journal of Gastroenterology, pp. 1000–1005, 2008.
[9] S. Hempel et al., “Probiotics for prevention and treatment of antibiotic-associated diarrhea,” JAMA, vol. 307, no. 18, pp. 1959–1969, 2012.
[10] G. R. Gibson and M. B. Roberfroid, “Dietary modulation of colonic microbiota: prebiotics concept,” Journal of Nutrition, vol. 125, no. 6, pp. 1401–1412, 1995.
[11] E. Van Nood et al., “Duodenal infusion of donor feces for recurrent Clostridium difficile,” New England Journal of Medicine, vol. 368, no. 5, pp. 407–415, 2013.
[12] I. Sekirov, S. L. Russell, L. C. M. Antunes, and B. B. Finlay, “Gut microbiota in health and disease,” Physiological Reviews, 2010.
[13] B. U. Ruziev and D. K. Baimuratova, “The influence of internet and social networks on youth psychology,” PEDAGOG, vol. 8, no. 12, pp. 137–141, 2025.
[14] B. D. N. OA, “Drinking water quality in Uzbekistan: environmental challenges,” 2025.
[15] M. Orinovich, “Modern approach to treatment of ureaplasma infection,” Shokh Library, vol. 1, no. 12, 2025.
