Study the Effect of the Combination of Flavonoids of the Crocus Sativus Plant on Opportunistic Intestinal Microorganisms Against the Background of Acute Toxic Hepatitis Caused in Mice Under Study Conditions

Not only infectious factors, but also the expanding scale of industrial production today increase the occurrence of liver diseases against the background of the adverse effects of the production process or manufactured artificial synthetic substances, medicines on many human organs and systems. On the other hand, emerging liver diseases themselves cause serious medical, social and even economic problems due to the development of complications that cause disability and death, such as hepatocellular carcinoma or fibrosis and cirrhosis of the liver. The appearance of antibiotic-resistant strains used to prevent secondary infection during the improvement of antiviral or hepatoprotective agents for the treatment of liver diseases causes a decrease in the effectiveness of treatment. In this regard, the priority task is to determine the effectiveness of drugs with high hepatoprotective activity obtained on a plant basis, namely when using antibiotics. To this end, simultaneous activity against hepatoprotective and intestinal pathogenic strains against the background of acute toxic hepatitis was detected in laboratory white mice of Crocus savitus plant extract. Acute toxic hepatitis was caused in white mice by oral administration of a paracetamol solution (JSC Pharmstandard-Lexredstva Russia) at a dose of 1500 mg/kg once 2 times in a row. The solution of the studied plant extract was selected as a comparative drug together with ciprofloxacin 50 mg/kg in dose of 50 mg/kg using a special atraumatic probe from 3 days of the study, the drug Karsil was administered orally to white mice at a dose of 50 mg/kg together with ciprofloxacin 50 mg/kg for 14 days. And the control group was given distilled water corresponding to the volume of the test substance. In the experiments conducted, it was found that the studied plant extract not only exhibits high hepatoprotective activity, but also eliminates cases of dysbiosis, which can develop under the action of ciprofloxacin.