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International Journal of Integrative and Modern Medicine

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Estimation of Antiproliferative Activity of Modified Thio-Nucleosides on Mcf-7 Cells Line with Pure Bacteria Liquid

Vol. 2 No. 6 (2024): International Journal of Integrative and Modern Medicine:
Published : Jun 10, 2024

Sajjad Albasri (1), Aliaksei G. Sysa (2), Eugenii I. Kvasyuk (3), Eugenii R. Gritskevitch (4)

(1) Student of environmental medicine faculty, ISEI BSU, Uzbekistan
(2) Candidate of science (biochemistry), docent (associate professor); dean of environmental medicine faculty, ISEI BSU, Uzbekistan
(3) Doctor of science (chemistry), full professor; professor at the department of environmental chemistry and biochemistry, environmental medicine faculty, ISEI BSU, Uzbekistan
(4) Candidate of science (biology), docent (associate professor); associate professor of immunology department, environmental medicine faculty, ISEI BSU., Uzbekistan
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Abstract:

Thio-nucleosides, characterized by the replacement of an oxygen atom with a sulfur atom in the nucleobase or sugar moiety, exhibit unique chemical and biological properties that make them promising candidates for therapeutic applications. In this study, we investigate the antiproliferative activity of four thio-nitrogen bases and nucleosides, including 2-mercaptopurine, thioguanine, 6-thioguanosine, and 2'-deoxy-6-thioguanosine, as well as Desulfated Aztreonam and 2-(Benzylsulfanyl)-1-hydroxyadenosine, against the MCF-7 human breast adenocarcinoma cell line.