Estimation of Antiproliferative Activity of Modified Thio-Nucleosides on Mcf-7 Cells Line with Pure Bacteria Liquid
Keywords:
MCF-7, anticancer activity, thionucleosidesAbstract
Thio-nucleosides, characterized by the replacement of an oxygen atom with a sulfur atom in the nucleobase or sugar moiety, exhibit unique chemical and biological properties that make them promising candidates for therapeutic applications. In this study, we investigate the antiproliferative activity of four thio-nitrogen bases and nucleosides, including 2-mercaptopurine, thioguanine, 6-thioguanosine, and 2'-deoxy-6-thioguanosine, as well as Desulfated Aztreonam and 2-(Benzylsulfanyl)-1-hydroxyadenosine, against the MCF-7 human breast adenocarcinoma cell line.