Determination of the Specific Activity of “Vaidaz” Gel

Abstract

This study investigates the specific activity and antimicrobial properties of “Vaidaz” gel (15%, Sample 01, Shelf Life 3 years), developed by the Department of Pharmaceutical Production Organization and Quality Management of Medicines at Tashkent Pharmaceutical Institute. The primary objective was to evaluate the gel's anti-inflammatory and antimicrobial effects through both biological and microbiological methods. The research demonstrated that “Vaidaz” gel exhibits significant anti-inflammatory activity, comparable to “Fastum gel”, with a reduction in paw volume by 53.5% to 75.2% in rats after histamine-induced inflammation. In addition, the antimicrobial efficacy of “Vaidaz” gel was assessed through the agar diffusion method, showing a 2.35-fold lesser inhibition zone compared to the standard drug “Oflomelida”. These findings confirm that “Vaidaz” gel not only provides anti-inflammatory benefits but also possesses minor antibacterial activity. The results were documented in accordance with GOST and O’zDSt 2762:2018 “Good Laboratory Practice,” validating its potential as a promising therapeutic agent.