Clinical Characteristics and Outcomes of Preterm Infants with Respiratory Distress Syndrome: A Cross-Sectional Study in Tertiary Care Units
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Keywords

Preterm
Respiratory Distress Syndrome
Outcomes

How to Cite

Abdulhalim, D. A. Y. (2025). Clinical Characteristics and Outcomes of Preterm Infants with Respiratory Distress Syndrome: A Cross-Sectional Study in Tertiary Care Units. International Journal of Pediatrics and Genetics , 3(4), 21–26. Retrieved from https://medicaljournals.eu/index.php/IJPG/article/view/1715

Abstract

Background: Neonatal respiratory distress syndrome (RDS), also known as hyaline membrane disease, is an acute lung disorder of newborns caused by pulmonary surfactant deficiency and immature lung development. It predominantly affects premature infants, with clinical signs of respiratory distress typically appearing within minutes to hours after birth. RDS remains a critical problem in neonatology, despite advances in perinatal care.

Methods: A descriptive cross-sectional study was conducted in the neonatal intensive care unit of a tertiary care hospital in Baghdad, Iraq, at Al-Kadhimiya Teaching Hospital during period from 4 June 2023 to 6 June 2024. 56 preterm infants were included in the study. The study aimed to assess the clinical profile and outcomes of preterm infants diagnosed with respiratory distress syndrome (RDS) during this time. A total of

Results: More than half of the mothers (57.1%) were between 20 and 34 years of age, which is considered the optimal reproductive age group. Most pre-term infants (75.0%) received surfactant therapy, which is a key treatment for RDS. CPAP was the most used mode of respiratory support, applied in 50% of cases. The overall survival rate among preterm infants with RDS was 71.4%, while the mortality rate was 28.6%. The average NICU stay was approximately 12.3 days.

Conclusion: critical role of early gestational age, low birth weight, antenatal steroid administration, and neonatal complications in determining outcomes in preterm infants with RDS. Efforts to improve antenatal care, especially the use of corticosteroids, and to strengthen infection control practices in NICUs may significantly enhance survival outcomes.

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References

Grappone L, Messina F. Hyaline membrane disease or respiratory distress syndrome? A new approach for an old disease. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM). 2014;3(2):e030263-e.

Edwards MO, Kotecha SJ, Kotecha S. Respiratory distress of the term newborn infant. Paediatric respiratory reviews. 2013;14(1):29-37.

De Luca D, Autilio C, Pezza L, Shankar-Aguilera S, Tingay DG, Carnielli VP. Personalized medicine for the management of RDS in preterm neonates. Neonatology. 2021;118(2):127-38.

Mwita S, Jande M, Katabalo D, Kamala B, Dewey D. Reducing neonatal mortality and respiratory distress syndrome associated with preterm birth: a scoping review on the impact of antenatal corticosteroids in low-and middle-income countries. World journal of pediatrics. 2021;17:131-40.

Lassi ZS, Middleton PF, Crowther C, Bhutta ZA. Interventions to improve neonatal health and later survival: an overview of systematic reviews. EBioMedicine. 2015;2(8):985-1000.

Condò V, Cipriani S, Colnaghi M, Bellù R, Zanini R, Bulfoni C, et al. Neonatal respiratory distress syndrome: are risk factors the same in preterm and term infants? The Journal of Maternal-Fetal & Neonatal Medicine. 2017;30(11):1267-72.

Watterberg KL, Carlo WA, Brion LP, Cotten CM, Higgins RD, editors. Overview of the neonatal research network: history, contributions, challenges, and future. Seminars in perinatology; 2022: Elsevier.

Jackson P, Muyanja SZ, Trishul Siddharthan M. Health equity and check for updates respiratory diseases. Aiming to improve equity in pulmonary health, an issue of clinics in chest medicine, E-Book. 2023;44:623-34.

Mehrabadi A, Lisonkova S, Joseph K. Heterogeneity of respiratory distress syndrome: risk factors and morbidity associated with early and late gestation disease. BMC pregnancy and childbirth. 2016;16:1-10.

Baseer KAA, Mohamed M, Abd-Elmawgood EA. Risk factors of respiratory diseases among neonates in neonatal intensive care unit of Qena University Hospital, Egypt. Annals of global health. 2020;86(1):22.

Atasay B, Akın İM, Alan S. Respiratory distress and management strategies in the newborn. Respiratory Management of Newborns: IntechOpen; 2016.

Vidyasagar D, Velaphi S, Bhat VB. Surfactant replacement therapy in developing countries. Neonatology. 2011;99(4):355-66.

Adewuyi EO, Auta A, Khanal V, Tapshak SJ, Zhao Y. Cesarean delivery in Nigeria: prevalence and associated factors―a population-based cross-sectional study. BMJ open. 2019;9(6):e027273.

Thevathasan I, Said JM. Controversies in antenatal corticosteroid treatment. Prenatal diagnosis. 2020;40(9):1138-49.

Reshmi Y. Clinicoetiological profile of respiratory distress in neonates: Rajiv Gandhi University of Health Sciences (India); 2017.

Prodhan P, Lin J, Regan S, Westra J, Yager P, Karni-Sharoor S, et al. Critically Ill Infants with Respiratory Syncitial Virus and Acute Respiratory Failure: Initial Chest Radiological Patterns As Predictors of Outcome: 44. Pediatric Critical Care Medicine. 2005;6(1):113.

Blankenship SA, Brown KE, Simon LE, Stout MJ, Tuuli MG. Antenatal corticosteroids in preterm small-for-gestational age infants: a systematic review and meta-analysis. American journal of obstetrics & gynecology MFM. 2020;2(4):100215.