Sepsis in Children and Treatment

Sepsis remains one of the leading causes of morbidity and mortality in pediatric populations worldwide. It represents a life-threatening condition resulting from the body’s dysregulated response to infection, leading to organ dysfunction. Despite significant advancements in pediatric intensive care, the diagnosis and management of sepsis in children continue to pose major challenges due to age-specific physiological variations and subtle clinical presentations. This article aims to review the pathophysiology, clinical features, diagnostic approaches, and modern treatment strategies for pediatric sepsis. The paper also explores recent developments in antimicrobial therapy, immunomodulatory treatments, and supportive care, while analyzing data from several clinical studies. Findings indicate that early recognition, timely administration of antibiotics, and optimal fluid management are critical determinants of survival. Furthermore, the integration of sepsis bundles and updated WHO guidelines have significantly improved clinical outcomes in pediatric care units.