Prevalence of Iron Deficiency Anemia in children and its association with Dietary patterns
Downloads
Anemia is a serious global public health problem that mostly affects children under the age of six. It strongly impacts their behavior, psychomotor development, and cognitive abilities. The immune system & its defenses are also impacted on physical development. This study is strongly contributing to assess and enroll clinical findings for iron deficiency anemia in children and assessing the association of children's iron deficiency anemia association with dietary patterns. Our study was assessed clinical outcomes of children who suffer from iron deficiency anemia. Due to that, we collected medical records of children from Baghdad, Iraq hospitals during follow-up, ranging from March 2024 to March 2025. Our study conducted a comparative for 106 samples, where the first group shows 56 children with iron deficiency anemia and second group includes 50 children without iron deficiency anemia.
Furthermore, we enrolled clinical data of children in both groups, including hematological profiles and dietary patterns. Also, we determined the extend of association between iron deficiency anemia and dietary patterns. Based on collected clinical data, we noted a low in hemoglobin, serum ferritin, and serum iron in a group of children with iron deficiency anemia in comparison with children without iron deficiency anemia [(9.1 ± 0.8 g/dL), (8.5 ± 3.2 ng/mL), and (28.5 ± 10.1 μg/dL). Also, we defined the risk factors of children with iron deficiency anemia including excessive cow's milk, rare/never consumption of meat, and rare/never consumption of Vitamin C-rich foods. According to the association between iron deficiency anemia in children and dietary patterns, we found that tea consumption with meals and lack of iron-fortified formula had a significantly impact on iron deficiency anemia. Our study shows that poor eating habits had highly impact in children with iron deficiency anemia, where it public health initiatives and parent education should place a strong emphasis on the value for a balanced diet, iron supplements, and minimizing cow's milk consumption in early life.
1. Safiri S., Kolahi A.-A., Noori M., Nejadghaderi S.A., Karamzad N., Bragazzi N.L., Sullman M.J.M., Abdollahi M., Collins G.S., Kaufman J.S., et al. Burden of Anemia and Its Underlying Causes in 204 Countries and Territories, 1990–2019: Results from the Global Burden of Disease Study 2019. J. Hematol. Oncol. 2021;14:185.
2. National Health Commission of the People’s Republic of China State Council Information Office Press Conference on December 23, 2020-Transcript. [(accessed on 19 September 2023)]; Available online: https://www.gov.cn/xinwen/2020-12/24/content_5572983.htm.
3. Xu P.P., Zhang Q., Yang T.T., Xu J., Gan Q., Cao W., Li L., Pan H., Zhao W.H. Anemia prevalence and its influencing factors among students involved in the Nutrition Improvement Program for Rural Compulsory Education Students in 2019. Zhonghua Liu Xing Bing Xue Za Zhi. 2022;43:496–502.
4. Fuhrmann D., Knoll L.J., Blakemore S.-J. Adolescence as a Sensitive Period of Brain Development. Trends Cogn. Sci. 2015;19:558–566.
5. Chen M., Xiong J., Zhao L., Chen G., Zhang Q., Ding G. Epidemiological research progress on the relationship between children′s dietary patterns and health. Chin. J. Prev. Med. 2022;56:139–145.
6. Beard J.L. Iron Biology in Immune Function, Muscle Metabolism and Neuronal Functioning. J. Nutr. 2001;131:568S–580S.
7. Wang M. Iron Deficiency and Other Types of Anemia in Infants and Children. Am. Fam. Physician. 2016;93:270–278.
8. Schulz C.-A., Oluwagbemigun K., Nöthlings U. Advances in Dietary Pattern Analysis in Nutritional Epidemiology. Eur. J. Nutr. 2021;60:4115–4130.
9. .Zhao J., Li Z., Gao Q., Zhao H., Chen S., Huang L., Wang W., Wang T. A Review of Statistical Methods for Dietary Pattern Analysis. Nutr. J. 2021;20:37.
10. Zarate-Ortiz A.G., Melse-Boonstra A., Rodriguez-Ramirez S., Hernandez-Cordero S., Feskens E.J.M. Dietary Patterns and the Double Burden of Malnutrition in Mexican Adolescents: Results from ENSANUT-2006. Nutrients. 2019;11:2753.
11. Kito A., Imai E. The Association with Dietary Patterns and Risk of Anemia in Japanese Elderly. J. Nutr. Sci. Vitaminol. 2020;66:32–40.
12. Li L., Zhan S., Ye D., Tan H. Epidemiology. 8th ed. People’s Medical Publishing House, Beijing, China: 2017.
13. Du X., Tan W., Yang F., Ye J., Yang J. Research of prevalence and impact factors of anemia among primary and junior high school students in Guangzhou. Chin. J. Sch. Health. 2016;37:1845–1847.
14. National Health Commission of the People’s Republic of China. National Health Commission of the People’s Republic of China Work Plan of Chinese National Chronic Noncommunicable Disease and Nutrition Surveillance (Trial) National Health Commission of the People’s Republic of China; Beijing, China: 2014.
15. National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. China Food Composition Tables Standard Edition I. 6th ed. Volume 1. Peking University Medical Press; Beijing, China: 2022.
16. National Institute for Nutrition and Health Chinese Center for Disease Control and Prevention. China Food Composition Tables Standard Edition II. 6th ed. Volume 2. Peking University Medical Press; Beijing, China: 2022.
17. National Health and Family Planning Commission of the People’s Republic of China. Standards Press of China; Beijing, China: 2013. Anthropometric Measurements Method In Health Surveillance 2013.
18. De Onis M., Onyango A.W., Borghi E., Siyam A., Nishida C., Siekmann J. Development of a WHO Growth Reference for School-Aged Children and Adolescents. Bull. World Health Organ. 2007;85:660–667.
19. National Health and Family Planning Commission of the People’s Republic of China. Standards Press of China; Beijing, China: 2014. Screening standard for malnutrition of school-age children and adolescents, 2014.
20. World Health Organization; Geneva, Switzerland: 2011. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. (WHO/NMH/NHD/MNM/11.1).
21. Wang Y., Tian T., Pan D., Zhang J., Xie W., Wang S., Xia H., Dai Y., Sun G. The Relationship between Dietary Patterns and Overweight and Obesity among Adults in Jiangsu Province of China: A Structural Equation Model. BMC Public Health. 2021;21:1225.
22. Wang Y., Xie W., Tian T., Zhang J., Zhu Q., Pan D., Xu D., Lu Y., Sun G., Dai Y. The Relationship between Dietary Patterns and High Blood Glucose among Adults Based on Structural Equation Modelling. Nutrients. 2022;14:4111.
23. Choi H.-J., Lee H.-J., Jang H.B., Park J.Y., Kang J.-H., Park K.-H., Song J. Effects of Maternal Education on Diet, Anemia, and Iron Deficiency in Korean School-Aged Children. BMC Public Health. 2011;11:870.
24. Smith C., Gasparetto M., Jordan C., Pollyea D.A., Vasiliou V. The Effects of Alcohol and Aldehyde Dehydrogenases on Disorders of Hematopoiesis. Adv. Exp. Med. Biol. 2015;815:349–359.
25. He B., Chen Y., Zhu Y., Mai J., Jing J., Bao P., Yu M. The Relationship between BMI and Anemia in Children Aged 7–12 Years in Guangzhou in 2010. Chin J Prev Med. 2014;48:1115–1117.
26. Srivastava S., Kumar P., Paul R., Debnath P. Effect of Change in Individual and Household Level Characteristics on Anemia Prevalence among Adolescent Boys and Girls in India. BMC Public Health. 2022;22:1478.
27. Liang J., Mai J. Analysis of the age characteristics of puberty sexual development in adolescents in Guangzhou. Chin. J. Sch. Health. 2012;33:1493–1495.
28. Luo J., Tang Y., Duan R., Yang M., Liu Y., Xue H., Tian G., Chen G. Onset and development trends of male puberty. Chin. J. Sch. Health. 2015;36:1756–1760.
29. .Xu H., Nie S., Meng R., Xu Y., Xia L., Li J. Prevalence and related physical factors of anemia among primary and high school students in Guangdong province. Chin. J. Public Health. 2018;34:1136–1139.
30. Teixeira B., Afonso C., Rodrigues S., Oliveira A. Healthy and Sustainable Dietary Patterns in Children and Adolescents: A Systematic Review. Adv. Nutr. 2022;13:1144–1185.


