Abstract
Atopic condition is a global problem of the 21st century as the number of children suffering from this disease is steadily increasing. Around the world, about 20% of the population seek medical help with clinical manifestations of this disease. In addressing public health issues, interest has increased in the incidence of vitamin D deficiency, its role in the pathogenesis of various diseases, as well as in ways to correct vitamin D deficiency. Vitamin D is involved not only in the metabolism of calcium and phosphates and has become a factor in ensuring the most important physiological functions. It has become a steroid hormone with endocrine, para- and autocrine effects. The predictive role of vitamin D in the development of autoimmune, cardiovascular pathologies, metabolic syndrome and its association with a high risk of mortality have been established. Vitamin D deficiency has become a global health problem in all countries of the world, especially in children's health.
References
Hendaus M.A., Jomha F.A., Ehlayel M. Allergic diseases among children: nutritional prevention and intervention //Ther Clin Risk Manag 2016; 7(12): 361–72. DOI: 10.1093/pch/pxx007
[Lityaeva L.A., Nosyreva S.Yu. Epigenetic risk factor of fetal sensitization to allergens in the system mother–fetus–newborn. Detskie infektsii (Children infections) 2017; 16(4): 25–29. (in Russ)]
Bulatova Е.М., Boytsova Е.А., Shabalov А.М. Frequency of food intolerance and food allergy in children of Saint Petersburg. Pediatria. Journal named after G.N. Speransky 2014; 93(3): 14–21. (in Russ)
Chiappini E., Vierucci F., Ghetti F., de Martino M., Galli L. Vitamin D Status and Predictors of Hypovitaminosis D in Internationally Adopted Children. PLoS One 2016; 11(9): e0158469. DOI: 10.1371/journal.pone.0158469
Nabeta H.W., Kasolo J., Kiggundu R.K., Kiragga A.N., Kiguli S. Serum vitamin D status in children with protein-energy malnutrition admitted to a national referral hospital in Uganda. BMC Res Notes 2015; 7(8): 418. DOI: 10.1186/s 13104- 015-1395-2
Rathi N., Rathi A. Vitamin D and child health in the 21st century. Indian Pediatr 2011; 48(8): 619–625.
Bose S., Breysse P.N., McCormack M.C., Hansel N.N., Rusher R.R., Matsui E. et al. Outdoor exposure and vitamin D levels in urban children with asthma. Nutr J 2013; 12(12): 81. DOI: 10.1186/1475-2891-12-81
Fang-Mercado L.C., Urrego-Álvarez J.R., MerlanoBarón A.E., Meza-Torres C., Hernández-Bonfante L., LópezKleine L. et al. Influence of lifestyle, diet and vitamin D on atopy in a population of Afro-descendant Colombian children. Rev Alerg Mex 2017; 64(3): 277–290.
Science M., Maguire J.L., Russell M.L., Smieja M., Walter S.D., Loeb M. Prevalence and predictors of low serum 25-hydroxyvitamin D levels in rural Canadian children. Paediatr Child Health 2017; 22(3): 125–129. DOI: 10.1093/pch/ pxx007
Aglipay M., Birken C.S., Parkin P.C., Loeb M.B., Thorpe K., Chen Y. et al. Effect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy Children. JAMA 2017; 318(3): 245–254. DOI: 10.1001/jama. 2017. 8708
López-González D., Méndez-Sánchez L., Guagnelli M.Á., Clark P. Vitamin D deficiency in childhood: an opportunity for prevention. Bol Med Hosp Infant Mex 2015; 72(4): 225– 234. DOI: 10.1016/j.bmhimx. 2015.01.011
Chekalova N.G., Matveeva N.А., Silkin Yu.R. Chekalova S.A., Dodonov A.V., Kogevnikova T.M. Comprehensive assessment of the health of schoolchildren with different conditions of the musculoskeletal system. Gigiena i sanitariya 2014; 93(4): 66–70. (in Russ)
Miraglia Del Giudice M., Allegorico A. The Role of Vitamin D in Allergic Diseases in Children. Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13– 15, 2015. J Clin Gastroenterol 2016; 50(2): 133–135. DOI: 10.1097/MCG.0000000000000679
Zhang M., Shen F., Petryk A., Tang J., Chen X., Sergi C. “English Disease”: Historical Notes on Rickets, the Bone-Lung Link and Child Neglect Issues. Nutrients 2016; 8(11): 722.
Смирнова Г.И., Румянцев Р.Е. Витамин D и аллергические болезни у детей: обзор. Российский педиатрический журнал 2017; 20(3): 166–172. [Smirnova G.I., Rumyantsev R.Е. Vitamin D and allergic diseases in children: review. Rossijskii pediatricheskii zhurnal (Russian journal of pediatrics) 2017; 20(3): 166–172. (in Russ)]
Yang A.R., Kim Y.N., Lee B.H. Dietary intakes and lifestyle patterns of Korean children and adolescents with atopic dermatitis: Using the fourth and fifth Korean National Health and Nutrition Examination Survey (KNHANES IV, V), 2007–11. Ecol Food Nutr 2016; 55(1): 50–64. DOI: 10.1080/03670244.2015.1072813
Kolokotroni O., Middleton N., Kouta C., Raftopoulos V., Yiallouros P.K. Association of Serum Vitamin D with Asthma and Atopy in Childhood: Review of Epidemiological Observational Studies. Mini Rev Med Chem 2015; 15(11): 881–899.
Tolppanen A.M., Sayers A., Granell R., Fraser W.D., Henderson J., Lawlor D.A. Prospective association of 25-hydroxyvitamin d3 and d2 with childhood lung function, asthma, wheezing, and flexural dermatitis. Epidemiol 2013; 24(2): 310–319. DOI: 10.1097/EDE obo 13e318280dd5e
Willits E.K., Wang Z., Jin J., Patel B., Motosue M., Bhagia A. et al. Vitamin D and food allergies in children: A systematic review and meta-analysis. Allergy Asthma Proc 2017; 38(3): 21–28. DOI: 10.2500/app. 2017.38.4043
Sowell K.D., Keen C.L., Uriu-Adams J.Y. Vitamin D and Reproduction: From Gametes to Childhood. Healthcare (Basel) 2015; 3(4): 1097–1120. DOI: 10.3390/healthcare3041097
Ahmed S.Z., Jaleel A., Hameed K., Qazi S., Suleman A. Does vitamin D defictency contribute to the severity of asthma in children and adults? J Ayub Med Coll Abbottabad 2015; 27(2): 458–463.
San T., Muluk N.B., Cingi C. 1,25 (OH)2D3 and specific IgE levels in children with recurrent tonsillitis, and allergic rhinitis. Int J Pediatr Otorhinolaryngol 2013; 77(9): 1506–1511. DOI: 10.1016/j. ijporl. 2013.06.019
Caprio M., Infante M., Calanchini M., Mammi C., Fabbri A. Vitamin D: not just the bone. Evidence for beneficial pleio tropic extraskeletal effects Eat Weight Disord - ROSSIYSKIY VESTNIK PERINATOLOGII I PEDIATRII, 2019; 64:(1). 2017; 22(1): 27–41. DOI: 10.1007/s40519-016-0312-6
Pike J.W., Meyer M.B., Bishop K.A. Regulation of target gene expression by the vitamin D receptor-an update on mechanisms. Rev Endocr Metab Disord 2012; 13 (1): 45–55. DOI: 10.1007/s11154-011-9198-9.
Mohammadi B., Najafi M., Farahmand F., Motamed F., Ghajarzadeh M., Mohammadi J. et al. Prevalence of vitamin D deficiency and rickets in children with cholestasis in Iran. Acta Med Iran 2012; 50(7):482–485.
Malespin M., Sleesman B., Lau A., Wong S.S., Cotler S.J. Prevalence and correlates of suspected nonalcoholic fatty liver disease in Chinese American children. J Clin Gastroenterol 2015; 49(4): 345–349. DOI: 10.1097MCG.0000000000000121
Lautenbacher L.A., Jariwala S.P., Markowitz M.E., Rastogi D. Vitamin D and pulmonary function in obese asthmatic children. Pediatr Pulmonol 2016; 51(12): 1276–1283. DOI: 10.1002/ppul. 23485
Sezer O.B., Buluş D., Hizli Ş., Andiran N., Yilmaz D., Ramadan S.U. Low 25 hydroxyvitamin D level is not an independent risk factor for hepatosteatosis in obese children. J Pediatr Endocrinol Metab 2016; 29(7): 783–788. DOI: 10.1515/ jpem-2015-0426
Feng H., Xun P., Pike K., Wills A.K., Chawes B.L., Bisgaard H. et al. In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies. J Allergy Clin Immunol 2017; 139(5): 1508–1517. DOI: 10.1016/j. jaci.2016.06.065
Wei Z., Zhang J., Yu X. Maternal vitamin D status and childhood asthma, wheeze, and eczema: A systematic review and meta-analysis. Pediatr Allergy Immunol 2016; 27(6): 612– 619. DOI: 10.1111/pai.12593
Н.Э. Юлдашова. Анализ и оценка качества жизни пациентов с акне. Modern Scientific Research International Scientific Journal. 2024y; 2 (3), p 352-357
N.E.Yuldashova, R.H.Sharipov, Sh.A.Khusinova. To evaluate the effectiveness of HPV elimination using recombinant interferon Alpha-2b; Modern Scientific Research International Scientific Journal, 2024y; Vol 2 №3, p371-377(in Russ)
Аблакулова М.Х. Of the Efficiency of the Dermatoscopic Method for the Differential Diagnosis of Mycosis and Alopecia in Children. Web of Synergy: International Interdisciplinary Research Journal 2023 y;Volume 2 Issue 1, р 133-137
N.E. Yuldashova. A new look at the treament of papiloma virus infection; Modern Scientific Research International Scientific Journal. 2024y; Vol.2 №2, p 249-253
R.X.Sharipov, N.E.Yuldashova. Justification of The Need to Determine the Level Of 25(OH) D 3 In the Blood Serum of Children to Assess the Quality of Rickitis Prevention; Journal of Advanced Zoology. 2024y; 44 (S-6), p1483-1486
Khakimova L.R. Efficiency of the Method of Treatment of Atopic Dermatitis of the Face. Web of Synergy: International Interdisciplinary Research Journal. 2023 у; Volume 2 Issue 1, p141-144.