Hypertensive Crisis, its Complications and Medications Used in Hypertensive Crisis

Authors

  • Sevinch Eshmamatova Khudoynazarovna Department of pharmacology of Tashkent medical academy
  • Khabiba Shakarova Asomiddin qizi Department of pharmacology of Tashkent medical academy
  • Muslimakhon Kamolova Mirzokhidjon qizi Department of pharmacology of Tashkent medical academy
  • Ikhvoliddin Mirzaev Komiljon o‘g‘li Department of pharmacology of Tashkent medical academy
  • Sokhib Rashidov Zamon oʻgʻli Department of pharmacology of Tashkent medical academy

Keywords:

Systolic blood pressure, antihypertensive medication therapy, hypertensive emergencies

Abstract

In clinical practice, patients with hypertensive emergencies, malignant hypertension, and acute severe hypertension are managed differently. Important considerations that vary slightly across different diagnoses and clinical contexts are necessary when starting antihypertensive therapy and setting blood pressure goals in acute settings. The British and Irish Hypertension Society's position paper aims to give clinicians a framework for diagnosing, evaluating, and managing patients with hypertensive crisis, based on the critical appraisal of available evidence and expert opinion. Only a small percentage of hypertensive patients will experience a hypertensive crisis, despite the high prevalence of hypertension (HTN). In actuality, some hypertensive crisis patients do not disclose a history of hypertension or prior antihypertensive medication use. While heart-related symptoms (dyspnea, chest discomfort, arrhythmias, and syncope) are less common, most patients with hypertensive crises frequently describe non-specific symptoms. Depending on whether there is acute target organ damage or not, hypertensive crises can be classified as either hypertension emergencies or hypertensive urgencies. Since a different approach to therapy is required, which has a substantial impact on the morbidity and mortality of these patients, this differentiation is a very helpful classification in clinical practice. Therefore, in order to prevent additional injury or deterioration of the target organs, it is extremely important for the emergency department physician to recognize hypertensive situations and treat them with blood pressure-lowering drugs. In an attempt to enhance the understanding, identification, risk assessment, and management of hypertensive crises in patients sent to the emergency room, this narrative review aims to provide an overview of the most recent data.

References

Alley WD, Schick MA. Hypertensive Emergency. [Updated 2023 Jul 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from:

https://www.ncbi.nlm.nih.gov/books/NBK470371/

Aronow WS. Treatment of hypertensive emergencies. Ann Transl Med. 2017 May;5(Suppl 1):S5. doi: 10.21037/atm.2017.03.34.

Papadopoulos DP, Sanidas EA, Viniou NA, et al. Cardiovascular hypertensive emergencies. Curr Hypertens Rep 2015; 17:5. 10.1007/s11906-014-0515-z

Kulkarni, S., Glover, M., Kapil, V. et al. Management of hypertensive crisis: British and Irish Hypertension Society Position document. J Hum Hypertens 37, 863–879 (2023).

https://doi.org/10.1038/s41371-022-00776-9

Papadopoulos DP, Mourouzis I, Thomopoulos C, Makris T, Papademetriou V. Hypertension crisis. Blood Press (2010) 19(6):328–36. doi:10.3109/08037051.2010.488052

Pinna G, Pascale C, Fornengo P, Arras S, Piras C, Panzarasa P, et al. Hospital admissions for hypertensive crisis in the emergency departments: a large multicenter Italian study. PLoS One (2014) 9(4):e93542. doi:10.1371/journal.pone.0093542

Taylor DA. Hypertensive crisis: a review of pathophysiology and treatment. Crit Care Nurs Clin North Am (2015) 27(4):439–47. doi:10.1016/j.cnc.2015.08.003

Al Bannay R, Böhm M, Husain A. Heart rate differentiates urgency and emergency in hypertensive crisis. Clin Res Cardiol (2013) 102(8):593–8. doi:10.1007/s00392-013-0570-5

Varounis C, Katsi V, Nihoyannopoulos P, Lekakis J and Tousoulis D (2017) Cardiovascular Hypertensive Crisis: Recent Evidence and Review of the Literature. Front. Cardiovasc. Med. 3:51. doi: 10.3389/fcvm.2016.00051

Mancia G, Kreutz R, Brunström M, et al. 2023 ESH Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens 2023; 41:1874-2071. doi:10.1097/HJH.0000000000003480

Salkic S, Batic-Mujanovic O, Ljuca F, Brkic S. Clinical presentation of hypertensive crises in emergency medical services. Mater Sociomed. 2014; 26(1):12-16. doi:10.5455/msm.2014.26.12-16

Talle MA, Ngarande E, Doubell AF, Herbst PG. Cardiac complications of hypertensive emergency: Classification, diagnosis and management challenges. J Cardiovasc Dev Dis.

;9(8):276. doi:10.3390/jcdd9080276

Ipek E, Oktay AA, Krim SR. Hypertensive crisis: An update on clinical approach and management. Curr Opin Cardiol. 2017;32(4):397-406. doi:10.1097/HCO.0000000000000398

Domek M, Gumprecht J, Lip GYH, Shantsila A. Malignant hypertension: does this still exist? J Hum Hypertens. 2020; 34:1–4.

Shah BM, Sadaka A, Berry S, Malik A, Lee AG. Bilateral disc edema in hypertensive emergency. Can J Ophthalmol J Can d’ophtalmol. 2018; 53:e113–e5.

Ayaz SI, Sharkey CM, Kwiatkowski GM, et al. Intravenous enalaprilat for treatment of acute hypertensive heart failure in the emergency department. Int J Emerg Med 2016; 9:28.

1186/s12245-016-0125-4

Tsivgoulis G, Katsanos AH, Butcher KS, et al. Intensive blood pressure reduction in acute intracerebral hemorrhage: a meta-analysis. Neurology 2014; 83:1523-9.

1212/WNL.0000000000000917

Jauch EC, Saver JL, Adams HP, Jr, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2013; 44:870-947.

1161/STR.0b013e318284056a

Papadopoulos DP, Sanidas EA, Viniou NA, et al. Cardiovascular hypertensive emergencies. Curr Hypertens Rep 2015; 17:5. 10.1007/s11906-014-0515-z

Watson K, Broscious R, Devabhakthuni S, Noel ZR. Focused Update on Pharmacologic Management of Hypertensive Emergencies. Curr Hypertens Rep. 2018 Jun 08; 20(7):56.

Shao PJ, Sawe HR, Murray BL, Mfinanga JA, Mwafongo V, Runyon MS. Profile of patients with hypertensive urgency and emergency presenting to an urban emergency department of a tertiary referral hospital in Tanzania. BMC Cardiovasc Disord. 2018 Aug 02;18(1):158

Pinna G, Pascale C, Fornengo P, Arras S, Piras C, Panzarasa P, et al. Hospital admissions for hypertensive crisis in the emergency departments: a large multicenter Italian study. PLoS One (2014) 9(4):e93542. doi:10.1371/journal.pone.0093542

Downloads

Published

2025-04-12

How to Cite

Khudoynazarovna, S. E., qizi, K. S. A., qizi, M. K. M., o‘g‘li, I. M. K., & oʻgʻli, S. R. Z. (2025). Hypertensive Crisis, its Complications and Medications Used in Hypertensive Crisis. International Journal of Alternative and Contemporary Therapy, 3(4), 38–43. Retrieved from https://medicaljournals.eu/index.php/IJACT/article/view/1712

Most read articles by the same author(s)

Similar Articles

<< < 1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.