NEURONAL BIOMARKERS OF BRAIN DAMAGE IN PREECLAMPSIA (LITERATURE REVIEW)

Preeclampsia (PE) is a multi-organ pregnancy complication accompanied by significant changes in the central nervous system. Neurological disorders in PE include headache, seizures, cognitive impairment, stroke, and posterior reversible encephalopathy syndrome (PRES). In recent years, increasing attention has been paid to the search for objective laboratory biomarkers reflecting the degree of neuronal and glial damage. Among these, neuronal proteins - GFAP, NfL, S100B, and NSE - have gained particular importance, reflecting different types of brain tissue damage. This review summarizes current literature data on the role of these markers in preeclampsia and their potential in diagnosis and prediction of neurological complications.