Toxic Nephropathy
Keywords:
kidneys, exogenous agents, impact, pathological changesAbstract
The article is devoted to the condition of the kidneys in poisoning. It was revealed that acute exogenous poisoning with systemic poisons, drugs with nephrotoxic potential, natural nephrotoxins, substances causing myolysis can cause the development of the renal phenotype of diffuse bilateral acute kidney injury - a private and most typical variant of toxic nephropathy, and also be the cause of tubulointerstitial nephritis with an outcome in nephrofibrosis or nephrogenic systemic fibrosis. Thus, the experimental substantiation of new approaches to the diagnosis of nephropathies of toxic genesis and the expansion of the capabilities of the methods used is a timely and relevant study of extremely important socio-economic significance.
References
Averyanov S.N., Amcheslavsky V.G., Bagaev V.G., et al. Determination of glomerular filtration rate in children: history and modern approaches // Pediatric pharmacology. - 2018. - Vol. 15, № 3. - P. 218-223. DOI: 10.15690/pf. v15i3.1901
Alyabyev F.V., Arbykin Yu.A., Tolmacheva S.K., Dolbnya A.D., Naltakyan A.G., Streltsova N.Yu., Sapega A.S., Paksyutkina A.V., Voznyak A.V. Dynamics of changes in some ultramicroscopic characteristics of the kidneys during acute alcohol intoxication in an experiment // Selected issues of forensic medical examination. - Khabarovsk, 2019. - № 18. - P. 36-39.
Belonogov I., Samokhin D. Toxicology and medical protection. - Minsk, "Higher School", 2014. - 416 p.
Berchenko M.A. The most common causes of death in the first hours of acetic acid poisoning. Bulletin of the Kazakh National Medical University. - 2015. - № 4. - P. 386-388.
5.Vdovina N.V. The human body: life processes and their regulation: monograph / N. V. Vdovina. - 2nd ed., revised. and additional. - Moscow: Yurait Publishing House, 2024. - 391 p.
Clinical guidelines "Acute kidney injury (AKI)" of the Ministry of Health of the Russian Federation. - URL: "https://rusnephrology.org/wp-content/uploads/2020/12/AKI_final.
Kuzmin O.B., Zhezha V.V., Belyanin V.V., Buchneva N.V., Landar L.N., Serdyuk S.V. Diagnostic and prognostic value of renal tubular damage biomarkers NGAL, KIM-1, L-FABP in patients with CKD. // Nephrology. - 2017. - № 21 (2). - P. 24-32. https://doi.org/10.24884/1561-6274-2017-21-2-24-32
Luzhnikov E.A. (ed.). Medical toxicology: national guidelines. Moscow: GEOTAR-Media; 2014. - 950 p.
Sivak K.V. Mechanisms of nephropathology of toxic genesis // Pathogenesis. - 2019. - Vol. 17, № 2. - P. 16-29.
Smirnov A.V., Dobronravov V.A., Rumyantsev A.Sh., Shilov E.M., Vatazin A.V., Kayukov I.G. et al. National guidelines. Acute kidney injury: basic principles of diagnosis, prevention and therapy. Part I. // Nephrology. - 2016. № 20 (1). - P. 79-104. https://doi.org/10.24884/1561-6274-2016-20-1-8-15
Amin R., Ahn S.-Y., & Moudgil A. Kidney and urinary tract disorders. //Biochemical and Molecular Basis of Pediatric Disease. - 2021. – Р. 167–228. doi:10.1016/b978-0-12-817962-8.00010-x
Cleto-Yamane T.L., Gomes CL.R., Suassuna J.H.R. et al. Acute Kidney Injury // Epidemiology in pediatrics. - 2019. - Vol. 41 (2). - Р. 275-283. DOI: 10.1590/2175-8239-JBN-2018-0127
Dettmeyer R.B. Forensic histopathology - fundamentals and perspectives (second edition). Cham, Switzerland: Springer International Publishing AG; 2018. https://doi.org/10.1007/978-3-319-77997-3
Eddy А.А. Drug-induced tubulointerstitial nephritis: hypersensitivity and necroinflammatory pathways. //Pediatr Nephrol. – 2020. - №35. – Р. 547-554. https://doi.org/10.1007/s00467-019-04207-9
Perazella M.A. Pharmacology behind common drug nephrotoxicities. //Clin J Am Soc Nephrol. – 2018. - №13. – Р. 1897-1908. https://doi.org/10.2215/CJN.00150118