Sympatheadrenal System and Lipid Peroxidation Processes in Young People Employed in the it Profession
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Despite national programs aimed at the prevention, early detection, and treatment of cardiovascular diseases, the problem remains highly relevant. In recent years, attention has been focused on the role of the sympathoadrenal system (SAS) in the pathogenesis of arterial hypertension. An acute release of catecholamines during stressful external influences is the earliest, due to stress and increased sympathetic nervous system tone, which is one of the key principles in the development of arterial hypertension in young people.
The aim of the study was to examine the characteristics of sympathoadrenal dysfunction and lipid peroxidation processes in young individuals working in the information technology field.
Materials and methods. Ninety men aged 25–44 years were examined; the average age was 33.2±0.93 years. Safe, instrumental, and distinctive laboratory research methods were used.
Results and Conclusions. It was established that young individuals actively working in the IT sector exhibit impaired sympathoadrenal system function, leading to increased excretion of catecholamines (primarily adrenaline and noradrenaline), disruption of the circadian rhythm of catecholamine excretion, decreased activity of monoamine oxidase (MAO), a key enzyme in catecholamine deamination, increased levels of vanillylmandelic acid, a quaternary metabolite of catecholamines, and increased levels of malondialdehyde (MDA), a secondary product of lipid peroxidation.
1. Decree of the President of the Republic of Uzbekistan dated January 28, 2022 No. UP-60 "On the Development Strategy of the New Uzbekistan for 2022-2026". Collection legislative acts .
2. Global trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies involving 104 million people. Noncommunicable Disease Risk Factors Collaboration (NCD-RisC). Lancet. 2021. PMID: 34450083. PMC free article.
3. Battistoni A., Canichella F., Pignatell G., et al.
Hypertension in young people: epidemiology, diagnostic evaluation, and therapeutic approach. // High Blood Press Cardiovasc Prev. 2015;22:381–388.doi:10.1007/s40292-015-0114-3.
4. Costa S, Lima K, Nobre A, et al. Hypertensive patients at high risk for cardiovascular disease and socioeconomic and health outcomes.
Rev. Assoc. Med Bras (1992). 2018; 64(7):601–10. doi:10.1590/1806-9282.64.07.601 .
5. Garafova A., Penesova A., Chizmarova E., et al. Cardiovascular and sympathetic states during mental stress load in young patients with hypertension and/or obesity. Physiol. Res. 2014; 63 (Supplement 4): S459–S67.
6. Oybekova G.S., Khuzhamberdiev M.A., Vakhabov B.M.
Current issues in modern cardiology: why is hypertension becoming more prevalent in younger people?
Medicine and sports. 2023; No. 4: 77-81. www.sportmed.uz ISSN 2181-998х 2023/4.
7. Oybekova G.S., Khuzhamberdiev M.A., Vakhabov B.M.
American Journal of Medicine and Medical Sciences (AJMMS) , USA , " SYMPATHATROADRENALIC ACTIVITY, CATECHOLAMINES AND PATHOGENESIS OF ARTERIAL HYPERTENSION IN THE YOUNG POPULATION " Volume: 4 Issue 6/June - 2024 . P. 124–127 https://academikpublishers.org
8. Nascimento B., Brant L., Yadgir S., et al. Prevalence, mortality, and morbidity associated with high systolic arterial blood pressure in Brazil from
9. 1990 to 2017: estimates from the Global Burden of Disease 2017 (GBD 2017) study. // Population Health Meter. 2020;18(Supplement 1):17. doi:10.1186/s12963-020-00218-z.
10. Yano Y, Stamler J, Garside D, et al. Isolated systolic hypertension in young and middle-aged adults and 31-year risk of cardiovascular mortality: the Chicago Heart Project Industrial Disease Detection Study. J Am Coll Cardiol. 2015 Feb 3;65(4):327-335. doi:10.1016/j.jacc.2014.10.060 .
11. Zhou B, Bentham J, Di Cesare M, et al. Global changes in blood pressure from 1975 to 2015: a final analysis of 1479 population-based studies involving 19 million people. participants. //Lancet. 2017; 389(10064): 37-55. doi:10.1016/S0140-6736(16)31919-5
12. World Health Organization. (2024). Hypertension. https://www.who.int/news-room/fact-sheets/detail/hypertension
13. American Heart Association. (2023). Stress and Heart Health. https://www.heart.org/en/healthy-living/healthy-lifestyle/stress-management/stress-and-heart-health
14. Zhang, W. et al. (2023). Sitting time at work and hypertension among IT workers. Journal of Occupational Health.
15. Smith, J. and Lee, K. (2022). Sedentary lifestyle and cardiovascular disease risk. Heart Journal
