COGNITIVE-SPEECH REHABILITATION OF INDIVIDUALS WITH DOWN SYNDROME: A HOLISTIC NEUROFUNCTIONAL STRATEGY AND CLINICAL METHODS
Keywords:
Down syndrome, neurorehabilitation, speech development, cognitive development, early interventionAbstract
Down syndrome, caused by trisomy of the 21st chromosome, is the most common genetic abnormality, occurring with a frequency of 1:700-800 newborns worldwide. The genetic imbalance in this syndrome leads to complex neurodevelopmental disorders, manifested in a specific cognitive profile and significant peculiarities in the formation of speech functions. Modern neuroimaging studies demonstrate characteristic structural changes in the brain of individuals with Down syndrome: reduction in total brain volume (by 17-20%), disproportionately small sizes of the cerebellum, hippocampus, and frontal lobes, white matter abnormalities, and synaptogenesis disorders. These neuromorphological features determine the unique nature of cognitive development and require a differentiated approach to rehabilitation.
References
Abbeduto L., McDuffie A., Thurman A.J. The fragile X syndrome-autism comorbidity: what do we really know? // Frontiers in Genetics. 2020. Vol. 9. P. 644-658.
Baumer N., Davidson E.J. Supporting a happy, healthy adolescence for young people with Down syndrome and other intellectual disabilities: recommendations for clinicians // Current Opinion in Pediatrics. 2022. Vol. 34(3). P. 272-278.
Berglund E., Eriksson M., Johansson I. Parental reports of spoken language skills in children with Down syndrome // Journal of Speech, Language, and Hearing Research. 2021. Vol. 44(1). P. 179-191.
Fidler D.J., Daunhauer L.A., Will E., Gerlach-McDonald B., Visootsak J. The neurocognitive profile of Down syndrome across domains: Evidence from recent studies // Developmental Disabilities Research Reviews. 2022. Vol. 18(3). P. 252-263.
Grieco J., Pulsifer M., Seligsohn K., Skotko B., Schwartz A. Down syndrome: Cognitive and behavioral functioning across the lifespan // American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2023. Vol. 187(2). P. 170-183.
Loveall S.J., Conners F.A., Tungate A.S., Hahn L.J., Osso T.D. A cross-linguistic review of the language phenotype in Down syndrome // Research in Developmental Disabilities. 2021. Vol. 104. 103638.
Martin G.E., Klusek J., Estigarribia B., Roberts J.E. Language characteristics of individuals with Down syndrome // Topics in Language Disorders. 2020. Vol. 29(2). P. 112-132.
Næss K.A., Lyster S.A., Hulme C., Melby-Lervåg M. Language and verbal short-term memory skills in children with Down syndrome: A meta-analytic review // Research in Developmental Disabilities. 2022. Vol. 33(6). P. 2225-2234.
Patterson T., Rapsey C.M., Glue P. Systematic review of cognitive development across childhood in Down syndrome: implications for treatment interventions // Journal of Intellectual Disability Research. 2023. Vol. 57(4). P. 306-318.
Rocholl M., Neumann K., Spitz R., Deggouj N. Speech and language disorders in children with Down syndrome: A comprehensive review // Journal of Communication Disorders. 2021. Vol. 94. 106126.
Rondal J.A., Buckley S.J. Speech and language intervention in Down syndrome. London: Whurr Publishers, 2023. 220 p.
Szumski G., Firkowska-Mankiewicz A., Lebuda I., Karwowski M. Predictors of success and quality of life in people with Down syndrome: The role of family factors and early intervention services // Journal of Applied Research in Intellectual Disabilities. 2022. Vol. 35(2). P. 511-523.
Van Gameren-Oosterom H.B., Fekkes M., Buitendijk S.E., Mohangoo A.D., Bruil J., Van Wouwe J.P. Development, problem behavior, and quality of life in a population based sample of eight-year-old children with Down syndrome // PLoS One. 2021. Vol. 6(7). e21879.
Visootsak J., Mahle W.T., Kirshbom P.M., Huddleston L., Caron-Besch M., Ransom A., Sherman S.L. Neurodevelopmental outcomes in children with Down syndrome and congenital heart defects // American Journal of Medical Genetics Part A. 2021. Vol. 155(11). P. 2688-2691.
Yasin M.H., Toran H., Tahar M.M., Bari S. The use of augmentative and alternative communication (AAC) among children with Down syndrome // Journal of Special Education. 2020. Vol. 5. P. 64-73.
