POST-INFECTIOUS EPILEPSY

Zhumanova Munisa Rashid qizi; Abdurazakov Isomiddin Holboy ogli; Mirzaeva Lobar Musoqil qizi; Khalilov Akbarzhon Ural ogli; Kasimov Arslanbek Atabaevich

Authors

Zhumanova Munisa Rashid qizi Clinical Resident, Department of Neurology Samarkand State Medical University
Abdurazakov Isomiddin Holboy ogli Clinical Resident, Department of Neurology Samarkand State Medical University
Mirzaeva Lobar Musoqil qizi Clinical Resident, Department of Neurology Samarkand State Medical University
Khalilov Akbarzhon Ural ogli Clinical Resident, Department of Neurology Samarkand State Medical University
Kasimov Arslanbek Atabaevich PhD, Associate Professor, Department of Neurology Samarkand State Medical University

Keywords:

epileptogenesis, chronic infections

Abstract

Recently, substantial evidence has been obtained regarding the possible involvement of inflammatory processes in epileptogenesis. Thus, several studies have established increased synthesis of specific inflammatory mediators in the brain of patients and corresponding activation of some pro-inflammatory pathways in seizure foci, as well as involvement of oxidative stress. Information has also emerged that some chronic infections, such as neurocysticercosis, HIV and herpes, without causing acute cerebral pathology, are capable of provoking epileptic seizures and even subsequent formation of refractory epilepsy. This review summarizes experimental and clinical research data on the connection between epilepsy and chronically occurring infectious diseases and neuroinflammation.