NEURODEGENERATION IN ALZHEIMER'S DISEASE: MODERN TREATMENT STRATEGIES AND REHABILITATION TECHNOLOGIES
Keywords:
Alzheimer's disease, neurodegeneration, therapeutic strategiesAbstract
This literature review is devoted to a comprehensive analysis of modern approaches to the treatment and rehabilitation of patients with Alzheimer's disease. The paper examines the pathophysiological mechanisms of neurodegeneration and their influence on the formation of therapeutic strategies. A critical analysis of the effectiveness of pharmacological methods is presented, including acetylcholinesterase inhibitors, NMDA receptor antagonists, and the latest drugs aimed at modifying the course of the disease. Special attention is paid to non-pharmacological approaches: cognitive stimulation, physical activity, diet therapy, and digital rehabilitation technologies. Promising research directions are considered, including immunotherapy, targeted effects on tau protein and beta-amyloid, as well as the use of neuromodulation. Issues of a personalized approach to therapy and rehabilitation of patients at different stages of the disease are discussed. Based on the systematization of modern scientific data, recommendations for optimizing treatment and rehabilitation measures are formulated, and priority directions for further research in this field are determined.
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