Morphological Characteristics of the Thymus in Acute Poisoning With Ento Defol
Keywords:
thymus gland, rat, defoliant, Ento Defol, acute poisoning, morphological changesAbstract
The article presents morphological changes developing in the thymus stroma during poisoning with Ento Defol. Specifically, a single high dose of the defoliant (1/10 LD50) resulted in a reactive thickening of collagen fibers in the interlobular barriers of the thymus and perivascular zones. These changes were assessed as a compensatory response developing against the background of interstitial edema and microcirculatory disturbances. A sharp increase in the number of mast cells in the perivascular and subcapsular zones, along with clear signs of degranulation, was also detected. Increased metachromasia indicated the activation of reactive inflammatory processes associated with the release of biologically active substances.
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