Abdullayeva Nargiza Nurmamatovna (1), Djurabekova Aziza Takhirovna (2), Doniyorov Davlatbek Raufovich (3)
Persistent neurological, cognitive, and psycho-emotional disorders are determined by a high level of disability and a decrease in the quality of life of patients due to chronic cerebrovascular disorders. According to foreign epidemiological studies, signs of chronic cerebrovascular disorders are detected in 30-40% of individuals over 55 years of age, and in recent years, there has been a trend towards the "rejuvenation" of vascular cerebral pathology.
1. Azizova R.B. Chronic Cerebrovascular Diseases: Clinical and Pathogenetic Aspects. Neurology and Neurosurgery of Uzbekistan. 2015;2:12-17.
2. Gusev E.I., Skvorsova V.I. Chronic forms of cerebrovascular diseases: pathogenesis, clinical presentation, diagnosis. Journal of Neurology and Psychiatry named after S.S. Korsakov. 2016;116 (6):4-11.
3. Daminova F.A., Bobomurodova Z.B. Inflammatory markers as predictors of the progression of chronic cerebral ischemia. Journal of Neurology of Uzbekistan. 2022;3:30-35
4. Zakharov V.V., Yakhno N.N. Cognitive impairments in chronic cerebral ischemia. Neurological Journal. 2020;25 (2):9-15.
5. Kalashnikova L.A., Gulevskaya T.S. The role of neural inflammation in the formation of chronic cerebral ischemia. Achievements of modern biology. 2019;139 (4):321-329.
6. Madjidova Yo.N. Cognitive impairments in chronic cerebral ischemia and ways to correct them. Journal of Theoretical and Clinical Medicine. 2019;4:45-49.
7. Parfenov V.A. Chronic cerebral ischemia: modern concepts of diagnosis and treatment. Medical advice. 2021;3:18-24.
8. Rakhimbayeva G.S. The role of systemic inflammation in the pathogenesis of cerebral vascular diseases. Bulletin of Samarkand State Medical University. 2021;1:38-43.
9. Skvorsova V.I., Shamalov N.A. Inflammation and Endothelial Dysfunction in Cerebrovascular Diseases. Annals of clinical and experimental neurology. 2018;12 (3):25-32.
10. Tuychibayeva N.M., Khamraev Kh.Kh. Clinical and diagnostic approaches in chronic cerebrovascular disorders. Medical Journal of Uzbekistan. 2020;6:22-27.Dinarello C.A. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunological Reviews. 2018;281(1):8–27.
11. Iadecola C. The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease. Neuron. 2017;96(1):17–42.
12. Iadecola C., Anrather J. The immunology of stroke: from mechanisms to translation. Nature Medicine. 2020;26(5):654–663.
13. Ilkhomovna K. M., Kadyrovich K. N., Eriyigitovich I. S. Clinical and demographicquality of life for patients with ischemic stroke in Uzbekistan //ACADEMICIA: An International Multidisciplinary Research Journal. – 2020. – Т. 10. – №. 10. – С. 883-889.
14. Kamalova M., Khaidarov N. Assessment of quality of life in ischaemic stroke patients //Збірник наукових праць Scientia. – 2021.
15. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurology. 2010;9(7):689–701.
16. Ridker P.M. Inflammation, C-reactive protein, and cardiovascular disease. Circulation Research. 2016;118(1):145–156.
17. Wardlaw J.M., Smith C., Dichgans M. Small vessel disease: mechanisms and clinical implications. Lancet Neurology. 2019;18(7):684–696.