A COMPREHENSIVE METHOD OF TREATMENT IN CHILDREN AND ADOLESCENTS WITH DISEASES OF THE TEMPOROMANDIBULAR JOINT SYSTEM

The study explores the processes of bone remodeling in the context of temporomandibular joint (TMJ) pathologies in children and adolescents, emphasizing their impact on mineral homeostasis and structural adaptation. The research aims to develop an effective diagnostic and comprehensive treatment approach for pediatric TMJ disorders. A clinical and dental examination was conducted on 300 children (130 boys and 170 girls), among whom 145 had TMJ pathologies (main group) and 155 were healthy controls. The study included a comparative analysis of clinical and biochemical data, integrating orthodontic and general treatment over 9 to 16 months. Diagnostic procedures involved clinical, biometric, and radiographic assessments. Results indicated significant oxidative stress and microbial contamination in TMJ-affected adolescents, along with a genetic predisposition to connective tissue dysplasia. Biochemical markers, including matrix metalloproteinases (MMP-1, MMP-3, and MMP-9), demonstrated substantial reductions post-treatment, while tissue inhibitor of metalloproteinases (TIMP-1) levels increased, indicating improved collagen integrity. Orthodontic evaluation revealed occlusal curve alterations and joint displacement patterns, further corroborating TMJ dysfunction. The study substantiates an 82% improvement in treatment efficacy through a combination of Wobenzyme, Omega 3-6-9, and orthodontic interventions. Early identification of metalloproteinase activity and connective tissue markers enables preemptive intervention, enhancing therapeutic outcomes. The findings underscore the necessity of integrating biochemical and orthodontic strategies for managing TMJ pathologies in pediatric populations.