Main Article Content
Abstract
The study explores the processes of bone remodeling in the context of temporomandibular joint (TMJ) pathologies in children and adolescents, emphasizing their impact on mineral homeostasis and structural adaptation. The research aims to develop an effective diagnostic and comprehensive treatment approach for pediatric TMJ disorders. A clinical and dental examination was conducted on 300 children (130 boys and 170 girls), among whom 145 had TMJ pathologies (main group) and 155 were healthy controls. The study included a comparative analysis of clinical and biochemical data, integrating orthodontic and general treatment over 9 to 16 months. Diagnostic procedures involved clinical, biometric, and radiographic assessments. Results indicated significant oxidative stress and microbial contamination in TMJ-affected adolescents, along with a genetic predisposition to connective tissue dysplasia. Biochemical markers, including matrix metalloproteinases (MMP-1, MMP-3, and MMP-9), demonstrated substantial reductions post-treatment, while tissue inhibitor of metalloproteinases (TIMP-1) levels increased, indicating improved collagen integrity. Orthodontic evaluation revealed occlusal curve alterations and joint displacement patterns, further corroborating TMJ dysfunction. The study substantiates an 82% improvement in treatment efficacy through a combination of Wobenzyme, Omega 3-6-9, and orthodontic interventions. Early identification of metalloproteinase activity and connective tissue markers enables preemptive intervention, enhancing therapeutic outcomes. The findings underscore the necessity of integrating biochemical and orthodontic strategies for managing TMJ pathologies in pediatric populations.
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References
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- Саидов А.А. Оценка некоторых показателей ротовой жидкости у детей с патологией височно-нижнечелюстного сустава // Monografia pokonferencyjna. Science,research, development #31. Rotterdam.- 2020.-P.30-32.
- Саидов А.А., Азимова Ш.Ш. Определение основный этиологических факторов у детей с дисфункцией височно-нижнечелюстного сустава // Monografia pokonferencyjna. Science, research, development #32. Berlin.-2020.-P. 48-51.
- Saidov A.A., Gaffarov S.A. Evaluation of some indicators of oral fluidin children with temporamandibular joint pathology// International journal of Innovations in engineering research and technology- 2020. -P.16-18.
- Саидов А.А., Гаффаров С.А.Совершенствование обследования детей с патологией височно-нижнечелюстного сустава вследствие аномалии прикуса // Методические рекомендации. – Бухара, 2020. – 22 с.
References
Gaffarov S.A., Saidov A.A. The importance of matrix metalloproteases in the pathology of the tempo-mandibular joint in children // International Journal on Integrated Education, Indonesia, 2020. Volume 3, Issue V, May. - Р. 65-68.Impact Faktor= 5.083
Gaffarov S.A., Saidov A.A., Yakubova F.Kh. An integrated approach to the diagnosis and treatment of a dysfunction of the temporomandibular joint in children and adolescents // Journal of critical reviews, 2020.Vol 7,Issue 17. – Р. 77-85.
Gaffarov S.A., Saidov A.A., Rakhmatullaeva D.U. Justification of the relationship of etiopathogenesis and complex diagnosis of the dysfunctional state of the temporamandibular join in children and adolescents // Journal of critical reviews, 2020. Vol 7,Issue 18. – Р. 881-891.
Saidov A.A. Assessment of some indicators of oral liquid in children with the pathology of the temior-lower under jaw joint // Asian Journal of Multidimensional Research , Indiya, 2020.Vol 9, Issue 1, january. – Р. 59-63.
Saidov A.A. Hygienic condition of the oral cavity during orthodontic treatment of children with temporomandibular joint dysfunction // The Pharma Innovation Journal. Indiya,2020. - № 9(6). - Р. 589-591.
Saidov A.A.,Olimov S.SH., Gaffarov S.A., Akhmadaliev N.N. The value of matrix metalloproteases and connective tissue markers in the pathology of temp-jaw joint in children // Journal of critical reviews, 2020. Vol 7, – P. 44-49.
Саидов А.А. Значение матриксных металлопротеаз при патологии височно-нижнечелюстного сустава у детей // VI Белорусский международный стоматологический конгресс. - Минск.- 2019.-С 67.
Саидов А.А. Роль маркеров соединительной ткани в развитии патологии височно-нижнечелюстного сустава у детей // «Актуальные проблемы практики ортопедической стоматологии». Научно-практическая онлайн конференция. –Бухара, - 2020.-С 14.
Saidov A.A., Gaffarov S.A. The role of matrix metalloproteases in early diagnostics in the pathology of the tempo-mandibular jointin children // Актуальные вызовы современной науки. Сборник научных трудов. Выпуск 4(48) часть1. Переяслав–2020-С.51-52.
Saidov A.A., Gaffarov S.A. Evaluation of certain indicators of oral fluidin children with temporomandibular joint pathology // Актуальныевызовысовременнойнауки. Сборник научных трудов. Выпуск 4(48) часть1. Переяслав–2020-С.53-55.
Саидов А.А. Оценка некоторых показателей ротовой жидкости у детей с патологией височно-нижнечелюстного сустава // Monografia pokonferencyjna. Science,research, development #31. Rotterdam.- 2020.-P.30-32.
Саидов А.А., Азимова Ш.Ш. Определение основный этиологических факторов у детей с дисфункцией височно-нижнечелюстного сустава // Monografia pokonferencyjna. Science, research, development #32. Berlin.-2020.-P. 48-51.
Saidov A.A., Gaffarov S.A. Evaluation of some indicators of oral fluidin children with temporamandibular joint pathology// International journal of Innovations in engineering research and technology- 2020. -P.16-18.
Саидов А.А., Гаффаров С.А.Совершенствование обследования детей с патологией височно-нижнечелюстного сустава вследствие аномалии прикуса // Методические рекомендации. – Бухара, 2020. – 22 с.