Content of Antimicrobial Proteins and Peptides in the Mixed Salvia of Pregnant Women with Dental Cariosics during Pregnancy
Keywords:
saliva composition; antimicrobial peptides; pregnant women oral health; lactoferrin; lysozyme; dental caries in pregnancy; hormonal changes; oral immunity; histatin-5; defensinsAbstract
Saliva plays a crucial role in the natural defense system of the oral cavity, particularly through the presence of antimicrobial proteins and peptides (AMPs) that help regulate the microbial balance. During pregnancy, hormonal changes can affect salivary composition, potentially reducing its protective properties. This study investigates the concentration and activity of selected AMPs — including lactoferrin, lysozyme, histatins, and defensins — in the mixed saliva of pregnant women diagnosed with active dental caries. A total of 90 participants were divided into caries-active and caries-free groups, and their unstimulated saliva samples were analyzed. Our results show a significant reduction in the levels of several AMPs in pregnant women with caries, particularly in the second and third trimesters. The findings suggest that altered salivary defense mechanisms may contribute to increased susceptibility to caries during pregnancy and highlight the potential of AMP profiling as a diagnostic tool in maternal oral health monitoring.
References
1. Воҳидов Элбек Раҳимович. Ҳомиладор аёлларда гестация даврининг стоматологик касалликлар ривожланишига таъсири // № 9 (71) 2024 Tibbiyotda yangi kun jurnali, -2024. –Б.413 - 415 (14.00.00; №22).
2. Ризаев Жасур Алимжанович., Воҳидов Элбек Раҳимович. Изучение этиопатогенетических аспектов стоматологических заболеваний у беременных и совершенствование мер их профилактики // Stomatologiya. – 2024. – №.2-3 (95-96). – С.117- 119. (14.00.00; № 12)
3. Воҳидов Элбек Раҳимович. Ҳомиладор аёлларда пародонт касалликлари ривожланишининг патогенетик жиҳатлари// Gumanitar va tabiiy fanlar jurnali Journal of humanities & natural sciences № 11(06), 2024. Vol.2
4. Jasur A. Rizayev, Elbek R. Vohidov, Nodira Sh.Nazarova. The importance of the clinical picture and development of the condition of periodont tissue diseases in opregnant women // Central Asian Journal of Medicine. №2. 2024. PP-5-89.
5. Vohidov Elbek Rahimovich. Assessment of Dental Status and Oral Health in Pregnant Women // American journal of pediatric Medicine and health sciences.Vol 2. 2024. PP-241-243.
6. Vohidov Elbek Rahimovich. Assessment of dental status and oral health in pregnant women // Биомедицина ва амалиёт журнали. № 3 –сон. 9 жилд. 2024. (14.00.24). Тошкент. Б. 16 – 20
7. Elbek R. Vohidov, Jasur A. Rizayev, Nodira Sh. Nazarova. Parodont to’qimasi kasalliklari holatini homilador ayollarda klinik ko’rinishi va rivojlanishining ahamiyati // Журнал стоматологии краниофасиальных исследований. № 5–сон. /3 -жилд. 2024. Самарқанд. Б. 66 – 70
8. Vohidov Elbek Rahimovich. Etiopathogenetic aspects of improving the prevention of dental diseases in pregnant women // Boffin Akademy Vol. 2 №1 2024. 2024-01-23
